Yang Yu-Shen, He Shi-Ling, Chen Wei-Can, Wang Cong-Mei, Huang Qiao-Mei, Shi Yan-Chuan, Lin Shu, He He-Fan
Department of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Neuroendocrinology Group, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Front Cell Neurosci. 2022 Oct 13;16:1024475. doi: 10.3389/fncel.2022.1024475. eCollection 2022.
Postoperative cognitive dysfunction (POCD), especially in elderly patients, is a serious complication characterized by impairment of cognitive and sensory modalities after surgery. The pathogenesis of POCD mainly includes neuroinflammation, neuronal apoptosis, oxidative stress, accumulation of Aβ, and tau hyperphosphorylation; however, the exact mechanism remains unclear. Non-coding RNA (ncRNA) may play an important role in POCD. Some evidence suggests that microRNA, long ncRNA, and circular RNA can regulate POCD-related processes, making them promising biomarkers in POCD diagnosis, treatment, and prognosis. This article reviews the crosstalk between ncRNAs and POCD, and systematically discusses the role of ncRNAs in the pathogenesis and diagnosis of POCD. Additionally, we explored the possible mechanisms of ncRNA-associated POCD, providing new knowledge for developing ncRNA-based treatments for POCD.
术后认知功能障碍（POCD），尤其是在老年患者中，是一种严重的并发症，其特征为术后认知和感觉功能受损。POCD的发病机制主要包括神经炎症、神经元凋亡、氧化应激、β-淀粉样蛋白（Aβ）积累和tau蛋白过度磷酸化；然而，确切机制仍不清楚。非编码RNA（ncRNA）可能在POCD中起重要作用。一些证据表明，微小RNA、长链ncRNA和环状RNA可调节与POCD相关的过程，使其成为POCD诊断、治疗和预后中有前景的生物标志物。本文综述了ncRNA与POCD之间的相互作用，并系统地讨论了ncRNA在POCD发病机制和诊断中的作用。此外，我们探讨了ncRNA相关POCD的可能机制，为开发基于ncRNA的POCD治疗方法提供了新知识。
