New insights into the role of ribonuclease P protein subunit p30 from tumor to internal reference.

Ribonuclease P protein subunit p30 () is a highly conserved housekeeping gene that exists in many species and tissues throughout the three life kingdoms (archaea, bacteria, and eukaryotes). is closely related to a few types of tumors in human diseases but has a very stable transcription level in most cases. Based on this feature, increasing number of studies have used as an internal reference gene. Here, the structure and basic functions of are summarized and the likely relationship between and various diseases in plants and human is outlined. Finally, the current application of as an internal reference gene and its advantages over traditional internal reference genes are reviewed. characteristics suggest that it has a good prospect of being selected as an internal reference; more work is needed to develop this research avenue.