模仿肌腱附着点的骨黏附各向异性坚韧水凝胶
Bone-Adhesive Anisotropic Tough Hydrogel Mimicking Tendon Enthesis.
作者信息
Choi Suji, Moon Jong Ryul, Park Nuri, Im Jihye, Kim Ye Eun, Kim Ji-Heung, Kim Jaeyun
机构信息
School of Chemical Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.
Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.
出版信息
Adv Mater. 2023 Jan;35(3):e2206207. doi: 10.1002/adma.202206207. Epub 2022 Dec 14.
Tendon consists of soft collagen, yet it is mechanically strong and firmly adhered to the bone owing to its hierarchically anisotropic structure and unique tendon-to-bone integration (enthesis), respectively. Despite the recent advances in biomaterials, hydrogels simultaneously providing tendon-like high mechanical properties and strong adhesion to bone-mimicking enthesis is still challenging. Here, a strong, stiff, and adhesive triple-network (TN) anisotropic hydrogel that mimics a bone-adhering tendon is shown. The tough adhesive TN hydrogel is developed by combining imidazole-containing polyaspartamide (providing multiple hydrogen bonds to the bone surface) and energy-dissipative alginate-polyacrylamide double-network. To mimic the anisotropic structure and high mechanical properties of tendons, the bone-adhered TN hydrogel is linearly stretched and subsequently fixed via secondary cross-linking. The resulting hydrogel exhibits high tensile modulus and strength while maintaining a high bone adhesion without chemical modification of the bone surface. Furthermore, a bone-ligament-bone structure with strong bone adhesion reminiscent of the natural ligament is realized.
肌腱由柔软的胶原蛋白组成,但由于其分层各向异性结构和独特的肌腱与骨结合(附着点),它在机械性能上很强且牢固地附着于骨。尽管生物材料最近取得了进展,但同时提供类似肌腱的高机械性能和对模仿骨附着点的强附着力的水凝胶仍然具有挑战性。在此,展示了一种模仿附着于骨的肌腱的强、硬且有粘性的三网络(TN)各向异性水凝胶。这种坚韧的粘性TN水凝胶是通过将含咪唑的聚天冬酰胺(为骨表面提供多个氢键)与耗能的藻酸盐 - 聚丙烯酰胺双网络结合而开发的。为了模仿肌腱的各向异性结构和高机械性能,将附着于骨的TN水凝胶线性拉伸,随后通过二次交联固定。所得水凝胶表现出高拉伸模量和强度,同时在不进行骨表面化学修饰的情况下保持高骨附着力。此外,还实现了一种具有强骨附着力、让人联想到天然韧带的骨 - 韧带 - 骨结构。