Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Department of Obstetrics and Gynecology, Kyoto University Hospital, Kyoto, Japan.
Int J Surg Pathol. 2023 Aug;31(5):765-771. doi: 10.1177/10668969221133346. Epub 2022 Oct 30.
The most common subtype of ovarian carcinoma associated with somatically derived yolk sac tumor (YST) is endometrioid carcinoma. Only two cases of ovarian mucinous carcinomas associated with YST have been reported; herein, we present three additional patients, along with a review of previous literature and our pathology archives to analyze the tumor prognosis. The patients' ages ranged from 38 to 53 years. Two patients had FIGO stage 1 tumors, and one patient had a stage 3 tumor. Two patients died of the disease within a year, and one patient survived with distant metastasis (32 months after surgery). In all three tumors, the YST-like component comprised less than 5% of the total tumor area. Together with the two previously reported mucinous carcinomas with a YST-like component, the prognosis of the five mucinous carcinomas with a YST-like component were compared with that of 19 conventional mucinous carcinomas resected at our hospital. The survival curves were estimated using the Kaplan-Meier method. As a result, the overall survival rate of patients with mucinous carcinomas with a YST-like component was significantly lower than that of patients with conventional mucinous carcinomas ( = .0014). Our study indicates that the presence of a YST-like component in mucinous carcinomas would be a strong prognostic indicator.
与体细胞衍生的卵黄囊瘤（YST）相关的最常见卵巢癌亚型是子宫内膜样癌。仅有两例与 YST 相关的卵巢黏液性癌的报道；在此，我们报告了另外三例患者，并回顾了先前的文献和我们的病理学档案，以分析肿瘤的预后。患者年龄 38 至 53 岁。两例患者为 FIGO 分期 1 期肿瘤，1 例为 3 期肿瘤。2 例患者在一年内死于该疾病，1 例患者存活且发生远处转移（术后 32 个月）。在所有三个肿瘤中，YST 样成分占总肿瘤面积的比例均小于 5%。连同先前报道的两个具有 YST 样成分的黏液性癌，对这五个具有 YST 样成分的黏液性癌与我院切除的 19 例常规黏液性癌的预后进行了比较。使用 Kaplan-Meier 法估计生存曲线。结果，具有 YST 样成分的黏液性癌患者的总生存率明显低于常规黏液性癌患者（=.0014）。我们的研究表明，黏液性癌中存在 YST 样成分是一个强烈的预后指标。
