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抗生素停药:西班牙全科医生对减少初级保健中抗生素不合理使用的新策略的看法。

Antibiotic deprescribing: Spanish general practitioners' views on a new strategy to reduce inappropriate use of antibiotics in primary care.

机构信息

Department of Public Health, General Practice, University of Southern Denmark, Odense, Denmark.

Health Centre Via Roma, University Institute in Primary Care Research Jordi Gol i Gurina, CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Barcelona, Spain.

出版信息

Eur J Gen Pract. 2022 Dec;28(1):217-223. doi: 10.1080/13814788.2022.2130887.

DOI:10.1080/13814788.2022.2130887
PMID:36314609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9629099/
Abstract

BACKGROUND

A doctor may recommend that a patient stop an antibiotic course before its scheduled completion time if further treatment may cause more harm than benefit.

OBJECTIVES

This study explores general practitioners' (GP) opinions about the use of antibiotic deprescribing (AD) in general practice.

METHODS

A cross-sectional, questionnaire-based study answered from February to March 2022. GPs ( = 6,083) affiliated with the largest Spanish scientific society of primary care were invited to participate. The survey included two statements related to use and fourteen views about AD rated by GPs using a 5-item Likert scale.

RESULTS

Eleven hundred and seven doctors completed the surveys (18.2%), of whom 92.5% (95% confidence interval [CI] 90.8-94%) reported having used the AD strategy in their practice at least once. GPs felt very confident in using a deprescribing strategy in patients with common cold and influenza (97.6% and 93.5%, respectively) but less with acute bronchitis (45.5%); 12.1% (95% CI, 10.2-14.2%) considered this practice harmful to patients. Respondents reported using AD more frequently when they initiated the antibiotic course (96.8%; 95% CI, 95.5-97.7) than when the treatment was initiated by another doctor (52.3%; 95% CI, 49.3-55.3%). However, doctors aged >60 years were more prone to use AD compared with younger colleagues (64.5% vs. 50%;  < 0.005).

CONCLUSION

The GPs in this study employ the strategy of AD. Nonetheless, essential differences lie in their views of the way the strategy is used. Further studies are warranted to explore the beliefs behind these perceptions and promote wider use of AD by GPs.

摘要

背景

如果进一步治疗弊大于利,医生可能会建议患者在预定疗程结束前停止使用抗生素。

目的

本研究探讨全科医生(GP)对抗生素减量(AD)在全科实践中应用的看法。

方法

这是一项在 2022 年 2 月至 3 月间进行的横断面、问卷调查研究。邀请隶属于西班牙最大的初级保健科学协会的全科医生参与。调查包括与使用 AD 相关的两个陈述和 14 个关于 AD 的观点,GP 用 5 项李克特量表对其进行评分。

结果

1107 名医生完成了调查(18.2%),其中 92.5%(95%置信区间 [CI] 90.8-94%)报告在实践中至少使用过一次 AD 策略。GP 对在普通感冒和流感患者中使用减量策略非常有信心(分别为 97.6%和 93.5%),但在急性支气管炎患者中信心较低(45.5%);12.1%(95% CI,10.2-14.2%)认为这种做法对患者有害。当他们启动抗生素疗程时(96.8%;95% CI,95.5-97.7),受访者报告比当治疗由另一位医生启动时(52.3%;95% CI,49.3-55.3%)更频繁地使用 AD。然而,年龄 >60 岁的医生比年轻同事更倾向于使用 AD(64.5%比 50%;<0.005)。

结论

本研究中的全科医生采用 AD 策略。然而,他们在使用该策略的方式上存在显著差异。需要进一步的研究来探索这些观念背后的信念,并促进全科医生更广泛地使用 AD。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0632/9629099/f1703aca7dc5/IGEN_A_2130887_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0632/9629099/fa9d462a133a/IGEN_A_2130887_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0632/9629099/f1703aca7dc5/IGEN_A_2130887_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0632/9629099/fa9d462a133a/IGEN_A_2130887_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0632/9629099/f1703aca7dc5/IGEN_A_2130887_F0002_C.jpg

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本文引用的文献

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Clin Microbiol Infect. 2022 Feb;28(2):147-148. doi: 10.1016/j.cmi.2021.11.009. Epub 2021 Nov 23.
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Efficacy and safety of discontinuing antibiotic treatment for uncomplicated respiratory tract infections when deemed unnecessary. A multicentre, randomized clinical trial in primary care.对于被认为不必要的单纯性呼吸道感染停用抗生素治疗的有效性和安全性。一项在初级保健机构进行的多中心随机临床试验。
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Appropriate deprescribing in older people: a challenging necessityCommentary to accompany themed collection on deprescribing.
老年人的适当减药:一项具有挑战性的必要举措——伴随减药专题集的评论。
Age Ageing. 2021 Sep 11;50(5):1516-1519. doi: 10.1093/ageing/afab142.
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Impact of Prior Antibiotic Use in Primary Care on Resistance to Third Generation Cephalosporins: A Case-Control Study.基层医疗中既往使用抗生素对第三代头孢菌素耐药性的影响:一项病例对照研究。
Antibiotics (Basel). 2021 Apr 16;10(4):451. doi: 10.3390/antibiotics10040451.
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Use of clinical vignettes to screen general practitioners who can participate in a clinical trial about stopping antibiotic treatment when this is no longer necessary.使用临床案例来筛选能够参与一项关于在抗生素治疗不再必要时停止使用抗生素的临床试验的全科医生。
Rev Esp Quimioter. 2021 Jun;34(3):267-268. doi: 10.37201/req/001.2021. Epub 2021 Mar 31.
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Patients receiving a high burden of antibiotics in the community in Spain: a cross-sectional study.西班牙社区中接受高抗生素负担的患者:一项横断面研究。
Pharmacol Res Perspect. 2021 Feb;9(1):e00692. doi: 10.1002/prp2.692.
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Barriers and facilitators to deprescribing in primary care: a systematic review.基层医疗中减药的障碍与促进因素:一项系统综述
BJGP Open. 2020 Aug 25;4(3). doi: 10.3399/bjgpopen20X101096. Print 2020 Aug.
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Overdiagnosis paradigm: not suitable for decreasing the overuse of antibiotics.过度诊断范式:不适合减少抗生素的过度使用。
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Adverse events in people taking macrolide antibiotics versus placebo for any indication.服用大环内酯类抗生素与服用安慰剂的人群因任何适应症出现的不良事件。
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