Lochbühler H
Anaesthesist. 1987 Jun;36(6):280-4.
Hypoplasia of the lungs is the cause of the high mortality of newborns with diaphragmatic hernia. Survival depends mainly on the development of the contralateral lung. Eighty percent of diaphragmatic hernias are postolateral hernias of the left side. The most serious postoperative complication is a relapse into fetal circulation with increased pulmonary vascular resistance and right-to-left shunting (Fig. 2). The clinical signs of diaphragmatic hernia are cyanosis and tachypnea. Intermittent suction via a nasogastric tube and early intubation without mask ventilation should be performed. The inspiratory pressure should not exceed 25 cm H2O to minimize the risk of pneumothorax. Survival of the baby is unlikely if the initial blood gas analysis shows pH less than 7.10, pO2 less than 50 mmHg, and pCO2 greater than 65 mmHg. Hypothermia should be strictly avoided because it leads to increased oxygen consumption. Intraoperative monitoring should include a precordial stethoscope, ECG, blood pressure, and rectal temperature. Anesthesia is maintained with fentanyl 0.02-0.03 mg/kg body wt. and pancuronium 0.08-0.1 mg/kg. One dose of atropine (0.02 mg/kg) is administered before fentanyl. Intraoperative ventilation is performed by hand or by use of a Siemens Servo ventilator. Thirty newborns were anesthetized for repair of a congenital diaphragmatic hernia with no intraoperative complication and an overall mortality of 27%.
肺发育不全是导致患有膈疝的新生儿死亡率高的原因。存活率主要取决于对侧肺的发育情况。80%的膈疝为左侧后外侧疝。最严重的术后并发症是复发至胎儿循环,伴有肺血管阻力增加和右向左分流(图2)。膈疝的临床症状为发绀和呼吸急促。应通过鼻胃管进行间歇性吸引,并在不进行面罩通气的情况下尽早插管。吸气压力不应超过25 cm H₂O,以将气胸风险降至最低。如果初始血气分析显示pH值低于7.10、pO₂低于50 mmHg且pCO₂高于65 mmHg,则婴儿存活的可能性不大。应严格避免体温过低,因为这会导致氧消耗增加。术中监测应包括心前区听诊器、心电图、血压和直肠温度。麻醉维持使用芬太尼0.02 - 0.03 mg/kg体重和潘库溴铵0.08 - 0.1 mg/kg。在给予芬太尼之前给予一剂阿托品(0.02 mg/kg)。术中通气可通过手动或使用西门子Servo呼吸机进行。30例新生儿接受了先天性膈疝修补术的麻醉,术中无并发症,总死亡率为27%。