Division of Women's Health, Research Institute of Traditional Asian Medicine, Kindai University School of Medicine, Osaka, Japan.
J Obstet Gynaecol Res. 2023 Feb;49(2):510-518. doi: 10.1111/jog.15484. Epub 2022 Nov 1.
Recently, the term premenstrual disorders (PMDs), which includes premenstrual syndrome and premenstrual dysphoric disorder as a continuum, has been proposed. Although the precise etiology of PMDs remains unknown, the involvement of hormonal fluctuations is clear. The brain transmitters, serotonin and γ-amino butyric acid, also seem to be involved. Serotonin reuptake inhibitors and oral contraceptives are the current mainstay of treatment, but these are insufficient. Even the currently used prospective two-period symptom diary is not widely used in actual clinical practice, creating a major problem of discrepancy between research and clinical practice. In this review, I would like to outline the latest information and problems in the etiology, diagnosis, and treatment of PMDs, with an emphasis on promising new therapies.
最近，提出了经前期障碍（PMD）这一术语，它将经前期综合征和经前期烦躁障碍作为一个连续体包含在内。尽管 PMD 的确切病因仍不清楚，但荷尔蒙波动的参与是明确的。大脑递质，5-羟色胺和γ-氨基丁酸，似乎也有涉及。5-羟色胺再摄取抑制剂和口服避孕药是目前的主要治疗方法，但这些方法并不充分。即使是目前使用的前瞻性两期症状日记也没有广泛用于实际临床实践中，这造成了研究与临床实践之间的重大差异问题。在这篇综述中，我想概述 PMD 的病因、诊断和治疗方面的最新信息和问题，重点介绍有前途的新疗法。
