[Seasonal fluctuations in the antibiotic sensitivity of Vibrio cholerae].

Sensitivity of group 01 Vibrio cholerae to 6 antibiotics including tetracycline, ampicillin, benzylpenicillin, polymyxin M, erythromycin and novobiocin was studied during various seasons within 3 years. The antibiotic sensitivity of the cultures was assayed with the method of two-fold dilutions in solid medium AGV. The "clonal sensitivity" of the populations of the same strains was estimated by the original method developed by the authors. There were observed seasonal biorhythms in manifestation of the physiological functions by Vibrio cholerae reflected in altered "clonal sensitivity" of the populations to the antibiotics, altered multiplication intensity during various periods and seasonal dissociation with respect to the cultural and morphological features in the strains with altered properties.