长非编码 RNA 对肿瘤微环境及肿瘤发生中髓系来源抑制细胞的调控作用

Modulation of Myeloid-derived Suppressor Cells by Long Non-coding RNAs in the Tumor Microenvironment and Tumorigenesis.

机构信息

Department of Anesthesiology, the third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, China.

Hebei Provincial Cancer Institute, Shijiazhuang 050011, Hebei, China.

出版信息

Discov Med. 2022 May-Jun;33(170):143-151.

PMID:36319601

Abstract

Myeloid-derived suppressor cells (MDSCs) constitute an important component in regulating immune responses in cancer. Long non-coding RNAs (lncRNAs) are untranslated functional RNA molecules. There is growing evidence that lncRNAs are involved in modulating transcriptional factors to become complex regulatory networks that regulate the immune function and activity of MDSCs in the immunosuppressive tumor microenvironment. This review focuses on the emerging role of lncRNAs in MDSCs activity. We summarize how lncRNAs modulate the differentiation, expansion, and immunosuppressive functions of MDSCs and the underlying mechanisms. It is hoped that lncRNAs targeting may prevent the growth and development of MDSCs in the immunosuppressive tumor microenvironment.

摘要

髓系来源的抑制细胞（MDSCs）构成了调节癌症中免疫反应的一个重要组成部分。长链非编码 RNA（lncRNA）是一种未翻译的功能 RNA 分子。越来越多的证据表明，lncRNA 参与调节转录因子，成为调节免疫功能和 MDSC 活性的复杂调控网络，在免疫抑制性肿瘤微环境中。本综述重点介绍了 lncRNA 在 MDSC 活性中的新作用。我们总结了 lncRNA 如何调节 MDSC 的分化、扩增和免疫抑制功能及其潜在机制。希望靶向 lncRNA 可以防止免疫抑制性肿瘤微环境中 MDSC 的生长和发展。