长非编码 RNA：髓源性抑制细胞活性的调控因子。
Long Non-coding RNAs: Regulators of the Activity of Myeloid-Derived Suppressor Cells.
机构信息
Facultad de Medicina, Universidad Autónoma de Baja California, Mexicali, Mexico.
Facultad de Enfermería, Universidad Autónoma de Baja California, Mexicali, Mexico.
出版信息
Front Immunol. 2019 Jul 25;10:1734. doi: 10.3389/fimmu.2019.01734. eCollection 2019.
Abstract
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent immunosuppressive functions. They play major roles in cancer and many of the pathologic conditions associated with inflammation. Long non-coding RNAs (lncRNAs) are untranslated functional RNA molecules. The lncRNAs are involved in the control of a wide variety of cellular processes and are dysregulated in different diseases. They can participate in the modulation of immune function and activity of inflammatory cells, including MDSCs. This mini review focuses on the emerging role of lncRNAs in MDSC activity. We summarize how lncRNAs modulate the generation, recruitment, and immunosuppressive functions of MDSCs and the underlying mechanisms.
摘要
髓系来源的抑制细胞（MDSCs）是一种具有强大免疫抑制功能的异质性细胞群体。它们在癌症和许多与炎症相关的病理状况中发挥主要作用。长非编码 RNA（lncRNA）是一类未翻译的功能性 RNA 分子。lncRNA 参与多种细胞过程的调控，在不同疾病中失调。它们可以参与调节免疫功能和炎症细胞的活性，包括 MDSCs。本综述重点介绍了 lncRNA 在 MDSC 活性中的作用。我们总结了 lncRNA 如何调节 MDSC 的产生、募集和免疫抑制功能，以及潜在的机制。
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