Womersley J, Stone D H
Arch Dis Child. 1987 Jul;62(7):717-20. doi: 10.1136/adc.62.7.717.
Data from the Glasgow Register of Congenital Malformations were used to investigate the epidemiology of congenital facial clefts over the period 1974-85. Facial clefts were registered in 247 infants representing a prevalence of 1.56 per 1000 total births. Cleft palate was more common than cleft lip, with cleft lip and palate occupying an intermediate position. More than half of the infants with facial clefts had associated defects. Males predominated for cleft lip; females for cleft palate. Cleft lip (alone) was more common in babies born to women aged 35 years and over. Sudden declines in registered prevalence were observed in 1978 and 1985. Clefts were more common in socioeconomically deprived areas of the city. In comparison with data from elsewhere, Glasgow seems to have a low rate of cleft lip, a high rate of cleft palate, and a high rate of associated defects. Many of the findings of cleft palate in Glasgow could be explained by the interaction of an unidentified environmental teratogen with a susceptible population.
利用格拉斯哥先天性畸形登记处的数据，对1974年至1985年期间先天性面部裂的流行病学情况进行了调查。247名婴儿登记有面部裂，占总出生人数的患病率为每1000例中有1.56例。腭裂比唇裂更常见，唇腭裂则处于中间位置。超过一半的面部裂婴儿伴有相关缺陷。唇裂中男性居多；腭裂中女性居多。单纯唇裂在35岁及以上女性所生婴儿中更为常见。1978年和1985年登记患病率出现突然下降。面部裂在该市社会经济贫困地区更为常见。与其他地方的数据相比，格拉斯哥的唇裂发生率似乎较低，腭裂发生率较高，相关缺陷发生率也较高。格拉斯哥许多腭裂的发现可以用一种不明环境致畸物与易感人群的相互作用来解释。
