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一项评估非综合征性口腔裂隙类型与儿童性别及母亲年龄之间关联的回顾性队列研究。

A Retrospective Cohort Study to Evaluate the Association Between Types of Nonsyndromic Oral Clefts and a Child's Gender and Maternal Age.

作者信息

Alrbata Raed H, Almaaiteh Hussein Y, Albdour Mohammad N, Alshammout Raghda W

机构信息

Orthodontic Department, Royal Medical Services, Amman, Jordan.

Plastic Surgery Department, Royal Medical Services, Amman, Jordan.

出版信息

J Int Soc Prev Community Dent. 2021 Jan 30;11(1):92-97. doi: 10.4103/jispcd.JISPCD_399_20. eCollection 2021 Jan-Feb.

DOI:10.4103/jispcd.JISPCD_399_20
PMID:33688478
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7934829/
Abstract

AIMS

To evaluate the association between nonsyndromic cleft lip with or without cleft palate (NSCL±P) anomaly and the affected child's gender and maternal age.

MATERIALS AND METHODS

Records of 141 newborns received at the orthodontic craniofacial clinic of the Jordanian Royal Rehabilitation Center between 2017 and 2019 were retrospectively analyzed. Two variables were paid attention to: child's gender and maternal age. Five cleft types were considered: unilateral CLP (right; URCLP and left; ULCLP), bilateral CLP (BCLP), isolated cleft palate (CP) and isolated cleft lip (CL). Maternal age was classified into four subgroups: "26-30" years, "31-35" years, "36-40" years, and "above 40" years. Chi-square test and multinomial logistic regression analysis were used to analyze the resultant data.

RESULTS

A significant occurrence of the NSCL±P in females was found compared with males. The different cleft types were found to be significantly associated with the different maternal age groups investigated. The ULCLP was the most prevalent cleft type for affected children among all maternal age groups except the "31-35" group, at which the BCLP exceeded.

CONCLUSIONS

The children's gender and the maternal age have a significant impact on defining the developing oral cleft types.

摘要

目的

评估非综合征性唇裂伴或不伴腭裂(NSCL±P)异常与患病儿童性别及母亲年龄之间的关联。

材料与方法

回顾性分析2017年至2019年期间约旦皇家康复中心正畸颅面诊所接收的141例新生儿记录。关注两个变量:儿童性别和母亲年龄。考虑了五种腭裂类型:单侧唇腭裂(右侧;URCLP和左侧;ULCLP)、双侧唇腭裂(BCLP)、单纯腭裂(CP)和单纯唇裂(CL)。母亲年龄分为四个亚组:“26 - 30”岁、“31 - 35”岁、“36 - 40”岁和“40岁以上”。采用卡方检验和多项逻辑回归分析对所得数据进行分析。

结果

发现女性NSCL±P的发生率显著高于男性。不同腭裂类型与所研究的不同母亲年龄组显著相关。除“31 - 35”组外,在所有母亲年龄组中,受影响儿童中最常见的腭裂类型是ULCLP,在“31 - 35”组中BCLP最为常见。

结论

儿童性别和母亲年龄对确定发育中的腭裂类型有显著影响。

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本文引用的文献

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Parental age in relation to the severity of cleft lip and/or palate.父母年龄与唇裂和/或腭裂严重程度的关系。
Orthod Craniofac Res. 2018 Nov;21(4):236-241. doi: 10.1111/ocr.12241. Epub 2018 Sep 6.
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Family history and risk factors for cleft lip and palate patients and their associated anomalies.唇腭裂患者及其相关异常的家族史和危险因素。
Stomatologija. 2017;19(3):78-83.
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Environmental factors related to the occurrence of oral clefts in a Brazilian subpopulation.巴西一个亚人群中与腭裂发生相关的环境因素。
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Maternal polymorphisms in folic acid metabolic genes are associated with nonsyndromic cleft lip and/or palate in the Brazilian population.在巴西人群中,叶酸代谢基因的母体多态性与非综合征性唇裂和/或腭裂相关。
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