Filippone G A, Fish S S, Lacouture P G, Scavone J M, Lovejoy F H
Arch Intern Med. 1987 Aug;147(8):1390-2.
The potential desorption of aspirin from activated charcoal was investigated in eight patients in a randomized cross-over study. Despite prebinding of aspirin, systemic absorption did occur. Desorption from activated charcoal was characterized by a peak salicylate concentration that was 16% of control and a time to peak salicylate concentration that was delayed in the study group. Bioavailability of aspirin from activated charcoal described by area under the curve was 19% of control. Elimination half-lives were similar in both groups until 12 hours after ingestion, but after 12 hours the half-life of the study group was prolonged while salicylate concentrations were undetectable in the control group. Fifteen percent to 20% of aspirin prebound to charcoal may desorb leading to systemic absorption. Furthermore, release from activated charcoal is initially delayed then sustained through 30 hours.
在一项随机交叉研究中，对8名患者体内活性炭上阿司匹林的潜在解吸附情况进行了调查。尽管阿司匹林预先结合在活性炭上，但仍发生了全身吸收。活性炭的解吸附表现为水杨酸盐浓度峰值为对照组的16%，且研究组中水杨酸盐浓度达到峰值的时间延迟。由曲线下面积描述的活性炭上阿司匹林的生物利用度为对照组的19%。两组的消除半衰期在摄入后12小时内相似，但12小时后，研究组的半衰期延长，而对照组中水杨酸盐浓度无法检测到。预先结合在活性炭上的阿司匹林有15%至20%可能解吸附，导致全身吸收。此外，从活性炭上的释放最初延迟，然后持续30小时。
