Lam S K, Chan P K, Wong J, Ong G B
Br J Surg. 1978 Nov;65(11):797-800. doi: 10.1002/bjs.1800651110.
Fasting serum gastrin levels and postprandial gastrin response were measured before and 1 month after highly selective vagotomy, truncal vagotomy with pyloroplasty and truncal vagotomy with antrectomy. The three groups of patients, 12 in each group, were closely matched for age, sex, maximum acid output and completeness of vagotomy. After highly selective and truncal vagotomy an identical and significant increase in fasting gastrin was observed, whereas after truncal vagotomy with antrectomy the pre- and postoperative fasting gastrin levels were not different. The net postprandial gastrin output over basal value was significantly increased after highly selective vagotomy, unchanged after truncal vagotomy and significantly lowered after truncal vagotomy with antrectomy. These results suggest the presence in the intact subject of a cholinergic inhibitory mechanism in the gastric body and fundus for the release of antral gastrin in the fasting and postprandial states and a possible cholinergic facilitatory mechanism for the release of antral gastrin after meals.
在高选择性迷走神经切断术、胃大部切除术加幽门成形术和胃大部切除术加胃窦切除术前及术后1个月，测量空腹血清胃泌素水平和餐后胃泌素反应。三组患者，每组12例，在年龄、性别、最大胃酸分泌量和迷走神经切断的完整性方面进行了密切匹配。高选择性迷走神经切断术和胃大部切除术后，空腹胃泌素均出现相同且显著的升高，而胃大部切除术加胃窦切除术前、后的空腹胃泌素水平无差异。高选择性迷走神经切断术后，餐后胃泌素净分泌量相对于基础值显著增加，胃大部切除术后无变化，胃大部切除术加胃窦切除术后显著降低。这些结果提示，在完整机体中，胃体和胃底存在一种胆碱能抑制机制，在空腹和餐后状态下抑制胃窦胃泌素的释放；而餐后胃窦胃泌素的释放可能存在一种胆碱能促进机制。
