Donovan I A, Owens C, Clendinnen B G, Griffin D W, Harding L K, Alexander-Williams J
Br J Surg. 1979 Mar;66(3):149-51. doi: 10.1002/bjs.1800660303.
In a prospective study of proximal gastric vagotomy and truncal vagotomy and antrectomy measurements were made, before and after operation, of acid output, gastrin output and gastric emptying of a solid and a liquid meat extract meal. No relationships were demonstrable between acid output and gastrin output. Truncal vagotomy and antrectomy (TVA) produced rapid early emptying of both meals combined with gross prolongation of the overall emptying of the solid meal. Truncal vagotomy and antrectomy reduced the intergrated gastrin output after either meal. Proximal gastric vagotomy (PGV) produced rapid early emptying of the liquid meal with no alteration in the early emptying of the solid meal; however, overall solid meal emptying was delayed. Proximal gastric vagotomy increased basal, peak and integrated gastrin output. In preoperative patients slow solid meal emptying was associated with higher gastrin output but after PGV the reverse was found, the slowest emptiers having the lowest gastrin output. These findings do not support the contention that a pyloroplasty should be added to PGV to reduce the hypergastrinaemia produced by the operation.
在一项关于近端胃迷走神经切断术以及全胃迷走神经切断术加胃窦切除术的前瞻性研究中，在手术前后分别对酸分泌量、胃泌素分泌量以及固体和液体肉提取物餐的胃排空情况进行了测量。酸分泌量和胃泌素分泌量之间未发现相关性。全胃迷走神经切断术加胃窦切除术（TVA）导致两种餐食的早期排空迅速，同时固体餐食的总体排空时间大幅延长。全胃迷走神经切断术加胃窦切除术降低了两种餐食后胃泌素的综合分泌量。近端胃迷走神经切断术（PGV）导致液体餐食的早期排空迅速，而固体餐食的早期排空无变化；然而，固体餐食的总体排空延迟。近端胃迷走神经切断术增加了基础、峰值和综合胃泌素分泌量。在术前患者中，固体餐食排空缓慢与较高的胃泌素分泌量相关，但在近端胃迷走神经切断术后发现情况相反，排空最慢的患者胃泌素分泌量最低。这些发现不支持在近端胃迷走神经切断术中加做幽门成形术以减少该手术所致高胃泌素血症的观点。
