Liu Xiaojuan, Lin Yanping, Yao Kangfei, Xie Junting, Xiao Jie, Cao Yong
Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou 510642, Guangdong, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China.
Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou 510642, Guangdong, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China.
Food Chem. 2023 Mar 15;404(Pt B):134194. doi: 10.1016/j.foodchem.2022.134194. Epub 2022 Sep 12.
This study sought to improve the biological fate of β-carotene obtained from spinach, using in vitro digestion, in situ single-pass intestinal perfusion, and in vivo approaches, to investigate the effects of excipient emulsions with medium- (MCT) and long-chain triglyceride (LCT) as a vehicle for improved health benefits of β-carotene. Results showed that the bioavailability and bioactivity of β-carotene were both significantly higher in the excipient emulsions relative to those without the emulsions. This was especially true when LCT was used as the vehicle. These results were confirmed by bioaccessibility, duodenal absorption, and in vivo absorption and metabolism. Furthermore, animal feeding studies revealed that LCT may have the potential to promote triglyceride and apo-B48 reconstitution and secretion. This suggested that LCT may facilitate the entry of carotenoids into circulation via the lymphatic pathway. These results highlight the importance of the optimization of excipient foods to improve the efficacy of lipophilic carotenoid.
本研究旨在通过体外消化、原位单通道肠道灌注和体内实验方法，改善从菠菜中提取的β-胡萝卜素的生物学命运，以研究以中链甘油三酯（MCT）和长链甘油三酯（LCT）为载体的辅料乳液对提高β-胡萝卜素健康益处的影响。结果表明，相对于未添加乳液的情况，β-胡萝卜素在辅料乳液中的生物利用度和生物活性均显著更高。当使用LCT作为载体时尤其如此。这些结果通过生物可及性、十二指肠吸收以及体内吸收和代谢得到了证实。此外，动物喂养研究表明，LCT可能具有促进甘油三酯和载脂蛋白B48重构及分泌的潜力。这表明LCT可能有助于类胡萝卜素通过淋巴途径进入循环。这些结果凸显了优化辅料食品以提高亲脂性类胡萝卜素功效的重要性。
