Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix, laboratoire de virologie, F-75013 Paris, France.
Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix, laboratoire de virologie, F-75013 Paris, France.
Infect Dis Now. 2023 Feb;53(1):104629. doi: 10.1016/j.idnow.2022.10.001. Epub 2022 Oct 30.
We aimed to characterize and compare the viral loads (VL) of the Omicron BA.1 and BA.2 lineages and the Delta variant in nasopharyngeal samples from newly diagnosed COVID-19 patients and their kinetics over time.
The kinetics of the VL were measured on the CT data from 215 SARS-CoV-2 positive patients who presented at least two positive PCRs a day apart and were screened for SARS-CoV-2 viral lineages.
We observed no significant difference in median CT value during the first diagnostic test between the Delta variant and the two Omicron lineages. However, the kinetics of CT decreases for the BA.1 and BA.2 lineage were significantly lengthier in time than the kinetics for the Delta variant. The BA.2 lineage presented lower median CT value (-2 CT) (inversely proportional to the VL) than the BA.1 lineage.
BA.2 Omicron lineage presented higher VL than BA.1 Omicron lineage at diagnostic. Omicron BA.1 and BA.2 lineages have more prolonged replication than the Delta variant.
我们旨在描述和比较新诊断为 COVID-19 的患者鼻咽样本中奥密克戎 BA.1 和 BA.2 谱系与德尔塔变异株的病毒载量 (VL)，并分析其随时间的变化。
对至少两次相隔一天以上的阳性 PCR 的 215 例 SARS-CoV-2 阳性患者的 CT 数据进行了 VL 动力学测量，并对 SARS-CoV-2 病毒谱系进行了筛查。
我们观察到，在首次诊断性检测中，德尔塔变异株和两种奥密克戎谱系之间的中位 CT 值没有显著差异。然而，BA.1 和 BA.2 谱系的 CT 值下降动力学时间明显比德尔塔变异株长。BA.2 谱系的中位 CT 值 (-2 CT) （与 VL 成反比）低于 BA.1 谱系。
在诊断时，奥密克戎 BA.2 谱系的 VL 高于 BA.1 谱系。奥密克戎 BA.1 和 BA.2 谱系的复制时间比德尔塔变异株更长。
