Groeger Justina L, Ayers Emmeline, Barzilai Nir, Beauchet Olivier, Callisaya Michele, Torossian Maral R, Derby Carol, Doi Takehiko, Lipton Richard B, Milman Sofiya, Nakakubo Sho, Shimada Hiroyuki, Srikanth Velandai, Wang Cuiling, Verghese Joe
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, United States.
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, United States.
Cereb Circ Cogn Behav. 2022 Sep 13;3:100151. doi: 10.1016/j.cccb.2022.100151. eCollection 2022.
Inflammation may play a role in Motoric Cognitive Risk (MCR) syndrome, a pre-dementia syndrome comprised of slow gait and cognitive complaints. Our objective was to examine associations of inflammatory biomarkers with MCR.
We examined association of interleukin-6 (IL-6) and C-reactive protein (CRP) with prevalent MCR using logistic regression in 3,101 older adults (52% female) from five cohorts (National Center for Geriatrics & Gerontology Study of Geriatric Syndromes [NCGG-SGS], Central Control of Mobility in Aging [CCMA], Tasmanian Study of Cognition and Gait [TASCOG], LonGenity, and Einstein Aging Study [EAS]). Associations were reported as odds ratios adjusted for sex, age, education, depressive symptoms, body mass index, and vascular diseases (aOR) with 95% confidence intervals (CI). Meta-analysis and analyses stratified by vascular disease were also done.
Although associations between higher (worse) CRP and IL-6 tertiles and MCR were only seen in three out of the five cohorts (EAS, TASCOG, and LonGenity), when a pooled meta-analysis was performed, a robust association was demonstrated. In meta-analysis, highest tertiles of IL-6 (aOR 1.57, 95%CI 1.01- 2.44) and CRP (aOR 1.65, 95%CI 1.09-2.48) was associated with MCR versus lowest tertiles in the pooled sample. Higher CRP was associated with MCR among those with vascular disease in TASCOG and LonGenity cohorts, and among those without vascular disease in EAS.
IL-6 and CRP levels are associated with MCR in older adults, and this association varies by presence of vascular disease.
炎症可能在运动认知风险（MCR）综合征中起作用，MCR综合征是一种由步态缓慢和认知主诉组成的痴呆前综合征。我们的目的是研究炎症生物标志物与MCR之间的关联。
我们在来自五个队列（老年综合征国家老年医学与老年学研究中心[NCGG-SGS]、衰老过程中运动的中枢控制[CCMA]、塔斯马尼亚认知与步态研究[TASCOG]、长寿研究和爱因斯坦衰老研究[EAS]）的3101名老年人（52%为女性）中，使用逻辑回归分析白细胞介素-6（IL-6）和C反应蛋白（CRP）与现患MCR的关联。关联以调整了性别、年龄、教育程度、抑郁症状、体重指数和血管疾病的比值比（aOR）及95%置信区间（CI）表示。还进行了荟萃分析以及按血管疾病分层的分析。
尽管在五个队列中的三个队列（EAS、TASCOG和长寿研究）中，仅观察到较高（较差）的CRP和IL-6三分位数与MCR之间的关联，但在进行汇总荟萃分析时，显示出了显著的关联。在荟萃分析中，与汇总样本中最低三分位数相比，IL-6（aOR 1.57，95%CI 1.01 - 2.44）和CRP（aOR 1.65，95%CI 1.09 - 2.48）的最高三分位数与MCR相关。在TASCOG和长寿研究队列中有血管疾病的人群以及EAS中无血管疾病的人群中，较高的CRP与MCR相关。
IL-6和CRP水平与老年人的MCR相关，并且这种关联因血管疾病的存在而有所不同。
