Department of Cardiology, Dong-A University Hospital, Busan, Korea.
J Korean Med Sci. 2022 Oct 31;37(42):e306. doi: 10.3346/jkms.2022.37.e306.
A 43-year-old man presented with cardiac arrest 2 days after the second coronavirus disease 2019 (COVID-19) vaccination with an mRNA vaccine. Electrocardiograms showed ventricular fibrillation and type 1 Brugada pattern ST segment elevation. The patient reported having no symptoms, including febrile sensation. There were no known underlying cardiac diseases to explain such electrocardiographic abnormalities. ST segment elevation completely disappeared in two weeks. Although there were no genetic mutations or personal or family history typical of Brugada syndrome, flecainide administration induced type 1 Brugada pattern ST segment elevation. This case suggests that COVID-19 vaccination may induce cardiac ion channel dysfunction and cause life threatening ventricular arrhythmias in specific patients with Brugada syndrome.
一名 43 岁男性，在接种第二剂 2019 冠状病毒病（COVID-19）mRNA 疫苗后 2 天发生心搏骤停。心电图显示心室颤动和 1 型 Brugada 样 ST 段抬高。患者自述无症状，包括发热感。无已知的潜在心脏疾病可解释这种心电图异常。ST 段抬高在两周内完全消失。尽管没有基因突变或 Brugada 综合征的个人或家族史，但氟卡尼给药诱导了 1 型 Brugada 样 ST 段抬高。本病例提示 COVID-19 疫苗接种可能导致心脏离子通道功能障碍，并在特定 Brugada 综合征患者中引起危及生命的室性心律失常。
