Engineering Research Center of Cell & Therapeutic Antibody, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Engineering Research Center of Cell & Therapeutic Antibody, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
J Control Release. 2022 Dec;352:586-599. doi: 10.1016/j.jconrel.2022.10.055. Epub 2022 Nov 3.
Hydrogen sulfide (HS), known as the third gasotransmitter, exerts various physiological functions including cardiac protection, angiogenesis, anti-inflammatory, and anti-cancer capability. Given its promising therapeutic potential as well as severe perniciousness if improper use, the sustained and tunable HS delivery systems are highly required for HS-based gas therapy with enhanced bioactivity and reduced side effects. To this end, a series of stimuli-responsive compounds capable of releasing HS (termed HS donors) have been designed over the past two decades to mimic the endogenous generation of HS and elucidate the biological functions. Further to improve the stability of HS donors and achieve the targeted delivery, various delivery systems have been constructed. In this review, we focus on the recent advances of an emerging subset, biomolecular-based HS delivery systems, which combine HS donors with biomolecular vectors including polysaccharide, peptide, and protein. We demonstrated their basic structures, building strategies, and therapeutic applications respectively to unfold their inherent merits endued by biomolecules including biocompatibility, biodegradability as well as expansibility. The varied development potentials of biomolecular-based HS delivery systems based on their specific properties are also discussed. At the end, brief future outlooks and upcoming challenges are presented as well.
硫化氢 (HS) 作为第三种气体递质，具有多种生理功能，包括心脏保护、血管生成、抗炎和抗癌能力。鉴于其作为治疗药物具有很大的潜力，但如果使用不当也会产生严重的毒性，因此需要开发具有持续可调的 HS 输送系统，以提高 HS 基气体治疗的生物活性并降低副作用。为此，在过去的二十年中，设计了一系列能够释放 HS 的响应性化合物（称为 HS 供体），以模拟 HS 的内源性产生并阐明其生物学功能。为了进一步提高 HS 供体的稳定性并实现靶向递送，构建了各种递送系统。在这篇综述中，我们重点介绍了新兴的生物分子 HS 递送系统的最新进展，该系统将 HS 供体与生物分子载体（包括多糖、肽和蛋白质）结合在一起。我们分别展示了它们的基本结构、构建策略和治疗应用，以揭示生物分子赋予它们的固有优势，包括生物相容性、可生物降解性和可扩展性。还根据其特定性质讨论了生物分子 HS 递送系统的不同发展潜力。最后，提出了简要的未来展望和即将面临的挑战。
