结核样匐行性脉络膜视网膜炎伴和不伴矛盾恶化的脉络膜毛细血管血流不足。

Choriocapillaris Flow Deficit in Tubercular Serpiginous-Like Choroiditis with and without Paradoxical Worsening.

机构信息

Eye Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE.

Department of Biomedical and Clinical Science "Luigi Sacco," Eye Clinic, Luigi Sacco Hospital, University of Milan, Milan, Italy.

出版信息

Ocul Immunol Inflamm. 2024 Aug;32(6):898-904. doi: 10.1080/09273948.2022.2140296. Epub 2022 Nov 3.

DOI:10.1080/09273948.2022.2140296

PMID:36328764

Abstract

PURPOSE

The aim is to analyze automated quantification of choriocapillaris flow deficit (CCFD) on swept-source (SS)-optical coherence tomography angiography (OCTA) in tubercular serpiginous-like choroiditis (TBSLC).

METHODS

In this prospective study, automated CCFD calculations were performed on SS-OCTA and compared with CCFD areas on indocyanine green angiography (ICGA). Patients were divided into two groups based on the occurrence of paradoxical worsening (PW).

RESULTS

Twenty-nine eyes (29 subjects; 18 males; mean age: 33±12 years) were included. The mean CCFD at baseline was 34.9 ± 4.3% on OCTA in eyes without PW and 35.4 ± 5.0% on SS-OCTA with PW (p = .77). At 4 and 12 weeks, CCFD on SS-OCTA improved to 30.6 ± 3.9% and 28.0 ± 4.2% (p < .001) without PW, respectively, and increased to 42.9 ± 4.4% and 48.8 ± 4.1% (p < .001) with PW, respectively. The SS-OCTA CCFD correlated well with ICGA (r = 0.48; p < .001).

CONCLUSIONS

Automated quantitative serial assessment of CCFD on SS-OCTA can serve as a useful biomarker of disease activity in eyes with TBSLC.

摘要

目的

分析结核性匐行性脉络膜病变（TBSLC）中扫频源（SS）-光相干断层扫描血管造影（OCTA）的脉络膜毛细血管血流缺损（CCFD）的自动量化。

方法

在这项前瞻性研究中，对 SS-OCTA 进行了自动 CCFD 计算，并与吲哚菁绿血管造影（ICGA）的 CCFD 区域进行了比较。根据是否出现矛盾性恶化（PW），将患者分为两组。

结果

共纳入 29 只眼（29 例；18 名男性；平均年龄：33±12 岁）。无 PW 眼的 OCTA 基线 CCFD 平均值为 34.9±4.3%，有 PW 眼的 SS-OCTA 为 35.4±5.0%（p=0.77）。在 4 周和 12 周时，无 PW 眼的 SS-OCTA 的 CCFD 分别改善至 30.6±3.9%和 28.0±4.2%（p<0.001），有 PW 眼的 CCFD 分别改善至 42.9±4.4%和 48.8±4.1%（p<0.001）。SS-OCTA 的 CCFD 与 ICGA 相关性良好（r=0.48；p<0.001）。