磷脂酰肌醇-3激酶-泛酸激酶4：辅酶A从头合成的新靶点。 - Suppr

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PI3K-PANK4: a new target for de novo synthesis of coenzyme A.

作者信息

Guan Jizhong, Zhang Long, Zhou Fangfang

机构信息

School of Medicine, Zhejiang University City College, Hangzhou, 310015, Zhejiang, China.

Institutes of Biology and Medical Science, Soochow University, Suzhou, 215123, China.

出版信息

Mol Biomed. 2022 Nov 4;3(1):33. doi: 10.1186/s43556-022-00094-z.

DOI:10.1186/s43556-022-00094-z

PMID:36329370

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9633907/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55f/9633907/38830e016aa2/43556_2022_94_Fig1_HTML.jpg

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本文引用的文献

PI3K drives the de novo synthesis of coenzyme A from vitamin B5.

Nature. 2022 Aug;608(7921):192-198. doi: 10.1038/s41586-022-04984-8. Epub 2022 Jul 27.

Targeting the PI3K/Akt signaling pathway in pancreatic β-cells to enhance their survival and function: An emerging therapeutic strategy for type 1 diabetes.

J Diabetes. 2022 Apr;14(4):247-260. doi: 10.1111/1753-0407.13252. Epub 2022 Feb 22.

Regulation of coenzyme A levels by degradation: the 'Ins and Outs'.

Prog Lipid Res. 2020 Apr;78:101028. doi: 10.1016/j.plipres.2020.101028. Epub 2020 Mar 29.

ATP citrate lyase: A central metabolic enzyme in cancer.

Cancer Lett. 2020 Feb 28;471:125-134. doi: 10.1016/j.canlet.2019.12.010. Epub 2019 Dec 9.

Coenzyme A biosynthetic machinery in mammalian cells.

Biochem Soc Trans. 2014 Aug;42(4):1112-7. doi: 10.1042/BST20140124.

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PI3K-PANK4: a new target for de novo synthesis of coenzyme A.

作者信息

Guan Jizhong, Zhang Long, Zhou Fangfang

机构信息

School of Medicine, Zhejiang University City College, Hangzhou, 310015, Zhejiang, China.

Institutes of Biology and Medical Science, Soochow University, Suzhou, 215123, China.

出版信息

Mol Biomed. 2022 Nov 4;3(1):33. doi: 10.1186/s43556-022-00094-z.

DOI:10.1186/s43556-022-00094-z

PMID:36329370

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9633907/

Abstract

摘要

相似文献

PI3K-PANK4: a new target for de novo synthesis of coenzyme A.

Mol Biomed. 2022 Nov 4;3(1):33. doi: 10.1186/s43556-022-00094-z.

PI3K-AKT Inhibits PANK4 to Promote De Novo Synthesis of Coenzyme A.

Cancer Discov. 2022 Oct 5;12(10):2229. doi: 10.1158/2159-8290.CD-RW2022-140.

PI3K drives the de novo synthesis of coenzyme A from vitamin B5.

Nature. 2022 Aug;608(7921):192-198. doi: 10.1038/s41586-022-04984-8. Epub 2022 Jul 27.

High glucose upregulates pantothenate kinase 4 (PanK4) and thus affects M2-type pyruvate kinase (Pkm2).

Mol Cell Biochem. 2005 Sep;277(1-2):117-25. doi: 10.1007/s11010-005-5535-1.

Low density lipoprotein binding and de novo synthesis of cholesterol in the neocortex and fetal zones of the human fetal adrenal gland.

Endocrinology. 1982 Jun;110(6):1994-8. doi: 10.1210/endo-110-6-1994.

The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis.

J Biol Chem. 2009 Feb 6;284(6):3521-8. doi: 10.1074/jbc.M806707200. Epub 2008 Dec 8.

Prognostic significance of the family expression in acute myeloid leukemia.

Ann Transl Med. 2019 Jun;7(12):261. doi: 10.21037/atm.2019.05.28.

The PduX enzyme of Salmonella enterica is an L-threonine kinase used for coenzyme B12 synthesis.

J Biol Chem. 2008 Apr 25;283(17):11322-9. doi: 10.1074/jbc.M800287200. Epub 2008 Feb 28.

Organ-specific alterations in fatty acid de novo synthesis and desaturation in a rat model of programmed obesity.

Lipids Health Dis. 2011 May 11;10:72. doi: 10.1186/1476-511X-10-72.

Mitogenic effect of lithium in FRTL-5 cells can be reversed by blocking de novo cholesterol synthesis and subsequent signal transduction.

Thyroid. 2000 Apr;10(4):305-11. doi: 10.1089/thy.2000.10.305.

本文引用的文献

PI3K drives the de novo synthesis of coenzyme A from vitamin B5.

Nature. 2022 Aug;608(7921):192-198. doi: 10.1038/s41586-022-04984-8. Epub 2022 Jul 27.

Targeting the PI3K/Akt signaling pathway in pancreatic β-cells to enhance their survival and function: An emerging therapeutic strategy for type 1 diabetes.

J Diabetes. 2022 Apr;14(4):247-260. doi: 10.1111/1753-0407.13252. Epub 2022 Feb 22.

Regulation of coenzyme A levels by degradation: the 'Ins and Outs'.

Prog Lipid Res. 2020 Apr;78:101028. doi: 10.1016/j.plipres.2020.101028. Epub 2020 Mar 29.

ATP citrate lyase: A central metabolic enzyme in cancer.

Cancer Lett. 2020 Feb 28;471:125-134. doi: 10.1016/j.canlet.2019.12.010. Epub 2019 Dec 9.

Coenzyme A biosynthetic machinery in mammalian cells.

Biochem Soc Trans. 2014 Aug;42(4):1112-7. doi: 10.1042/BST20140124.