Wu Qiongbo, Chen Zihao, Ding Yi, Tang Yunting, Cheng Yawei
Hainan Provincial Hospital of Traditional Chinese Medicine, Haikou, China.
Hainan Clinical Research Center for Preventive Treatment of Diseases, Haikou, China.
Front Nutr. 2022 Oct 18;9:1033129. doi: 10.3389/fnut.2022.1033129. eCollection 2022.
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease with high incidence and is closely related to metabolic syndrome. If not controlled, it may eventually become hepatocellular carcinoma (HCC). Ferroptosis, a non-apoptotic form of programmed cell death (PCD), is closely related to NAFLD and HCC, and the mechanisms of action involved are more complex. Some studies have demonstrated that many drugs inhibit ferroptosis and protect liver steatosis or carcinogenesis. The role of Traditional Chinese Medicine (TCM), especially herbs or herbal extracts, has received increasing attention. However, there are relatively few review articles on the regulation of NAFLD by TCM through ferroptosis pathway. Here, we summarize the TCM intervention mechanism and application affecting NAFLD/NAFLD-HCC regulation of ferroptosis. This article focuses on the relationship between ferroptosis and NAFLD or NAFLD-HCC and the protective effect of TCM on both by targeting ferroptosis. It not only summarizes the mechanism of early prevention and treatment of NAFLD, but also provides reference ideas for the development of TCM for the treatment of metabolic diseases and liver diseases.
非酒精性脂肪性肝病（NAFLD）是一种发病率较高的慢性肝病，与代谢综合征密切相关。若不加以控制，最终可能发展为肝细胞癌（HCC）。铁死亡是一种程序性细胞死亡（PCD）的非凋亡形式，与NAFLD和HCC密切相关，其涉及的作用机制更为复杂。一些研究表明，许多药物可抑制铁死亡并保护肝脏脂肪变性或癌变。传统中药（TCM）的作用，尤其是草药或草药提取物，已受到越来越多的关注。然而，关于中药通过铁死亡途径调控NAFLD的综述文章相对较少。在此，我们总结了中药干预影响NAFLD/NAFLD-HCC铁死亡调控的机制及应用。本文重点阐述铁死亡与NAFLD或NAFLD-HCC之间的关系，以及中药通过靶向铁死亡对二者的保护作用。它不仅总结了NAFLD早期防治的机制，还为中药治疗代谢性疾病和肝病的发展提供了参考思路。
