Pharmaceutical Sciences Research Division, Department of Pharmacy, Medical Supplies Center, People's Liberation Army (PLA) General Hospital, Beijing, China.
Medical School of Chinese People's Liberation Army (PLA), Beijing, China.
Front Immunol. 2022 Oct 18;13:1008285. doi: 10.3389/fimmu.2022.1008285. eCollection 2022.
Since immune system and internal environment are large and complex, the interpretation of the observed immune effect from the perspective of a single immune cell or antibody seems a little feeble. Many studies have shown that specific antibodies against " former" viruses have a reduced ability to neutralize "new" mutant strains. However, there is no comprehensive and clear view of whether there will be Antibody-dependent enhancement (ADE). We review the latest relevant studies, hoping to explain the ADE of SARS-CoV-2 infection sometimes observed in some patients.
由于免疫系统和内部环境庞大而复杂，从单个免疫细胞或抗体的角度来解释观察到的免疫效果似乎有点乏力。许多研究表明，针对“前”病毒的特定抗体中和“新”突变株的能力降低。然而，对于是否会发生抗体依赖性增强（ADE），目前尚无全面清晰的认识。我们回顾了最新的相关研究，希望能够解释有时在一些患者中观察到的 SARS-CoV-2 感染的 ADE 现象。
Zotero 插件