Wang Siwei, Zhou Yanhua, Huang Jiangrong, Li Huilin, Pang Huidan, Niu Dandan, Li Guangyao, Wang Fei, Zhou Zushan, Liu Zhenzhen
School of Basic Medicine, Yangtze University, Jingzhou, Hubei Province, China.
Honghu Hospital of Traditional Chinese Medicine, Affiliated Hospital of Yangtze University, Honghu, Hubei Province, China.
Eur J Immunol. 2023 Jan;53(1):e2249962. doi: 10.1002/eji.202249962. Epub 2022 Nov 18.
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by persistent articular inflammation and joint damage. RA was first described over 200 years ago; however, its etiology and pathophysiology remain insufficiently understood. The current treatment of RA is mainly empirical or based on the current understanding of etiology with limited efficacy and/or substantial side effects. Thus, the development of safer and more potent therapeutics, validated and optimized in experimental models, is urgently required. To improve the transition from bench to bedside, researchers must carefully select the appropriate experimental models as well as draw the right conclusions. Here, we summarize the establishment, pathological features, potential mechanisms, advantages, and limitations of the currently available RA models. The aim of the review is to help researchers better understand available RA models; discuss future trends in RA model development, which can help highlight new translational and human-based avenues in RA research.
类风湿性关节炎（RA）是一种慢性全身性自身免疫性疾病，其特征为持续性关节炎症和关节损伤。RA早在200多年前就有描述；然而，其病因和病理生理学仍未得到充分了解。目前RA的治疗主要是经验性的，或基于对病因的当前理解，疗效有限和/或有大量副作用。因此，迫切需要开发在实验模型中得到验证和优化的更安全、更有效的治疗方法。为了改善从实验室到临床的转化，研究人员必须仔细选择合适的实验模型并得出正确的结论。在此，我们总结了目前可用的RA模型的建立、病理特征、潜在机制、优点和局限性。本综述的目的是帮助研究人员更好地了解可用的RA模型；讨论RA模型开发的未来趋势，这有助于突出RA研究中基于新转化和人体的途径。
