Sleep Studies Unit/Laboratory of Physiology/Hospital for Rehabilitation of Craniofacial Anomalies - HRAC, University of São Paulo, Brazil.
Otolaryngology Section/Hospital for Rehabilitation of Craniofacial Anomalies - HRAC, University of São Paulo, Brazil.
Cleft Palate Craniofac J. 2024 Apr;61(4):574-583. doi: 10.1177/10556656221133606. Epub 2022 Nov 4.
To evaluate nasal cavity (NC) dimensions of individuals with cleft lip and/or palate (CL/P), obstructive sleep apnea (OSA), and primary snoring, by tomographic image analysis, compared to individuals with OSA without CL/P (N-CL/P). Cross-sectional and retrospective. Tertiary referral center. Patients were divided into 2 groups: (G1) CL/P + OSA or primary snoring, = 11; (G2) N-CL/P + OSA, = 13. NC tomographic images were reconstructed using ITK-SNAP software, and measurements were obtained from these three-dimensional models using SpaceClaim software. Total NC volumes, right and left NC volumes, and volumes of the nostril to the nasal valve (V1) and from the nasal valve to the superior limit of the nasopharynx (V2), cross-sectional areas, and perimeters. NC volumes (total, right, and left sides), V1, and V2, though smaller in the CL/P + OSA, did not differ significantly from the N-CL/P + OSA. Cross-sectional areas and perimeters of the superior limit of the nasopharynx, in the CL/P + OSA, presented significantly higher values compared to the N-CL/P + OSA ( ≤ .05). The internal nasal dimensions of patients with CL/P do not seem to be part of the etiopathogenesis, nor constitute a risk factor for OSA with greater severity, in this special group of patients.
为了通过断层图像分析评估唇裂和/或腭裂(CL/P)、阻塞性睡眠呼吸暂停(OSA)和原发性打鼾患者的鼻腔(NC)尺寸,并与无 CL/P 的 OSA 患者(N-CL/P)进行比较。这是一项横断面和回顾性研究。三级转诊中心。患者分为 2 组:(G1)CL/P+OSA 或原发性打鼾,=11;(G2)N-CL/P+OSA,=13。使用 ITK-SNAP 软件重建 NC 断层图像,并使用 SpaceClaim 软件从这些三维模型中获取测量值。总 NC 体积、右侧和左侧 NC 体积以及从鼻阀到鼻咽上缘的体积(V1)和从鼻阀到鼻咽上缘的体积(V2)、截面积和周长。尽管 CL/P+OSA 患者的 NC 体积(总、右和左侧)、V1 和 V2 较小,但与 N-CL/P+OSA 相比无显著差异。与 N-CL/P+OSA 相比,CL/P+OSA 患者的鼻咽上缘的截面积和周长呈现出显著更高的数值(≤.05)。在这个特殊的患者群体中,CL/P 患者的鼻腔内部尺寸似乎不是病因学的一部分,也不是 OSA 严重程度增加的危险因素。