Kandeel F R, Butt W R, London D R, Lynch S S, Edwards R L, Rudd B T
Clin Endocrinol (Oxf). 1978 Nov;9(5):429-41. doi: 10.1111/j.1365-2265.1978.tb03583.x.
An LH-RH test was performed before and 44 and 92 h after treatment with 2.5 mg oestradiol benzoate in 17 patients with a diagnosis of polycystic ovarian (PCO) disease. The responses were compared with the same tests performed on ten normal subjects during the early follicular phase of their menstrual cycles (days 4--6). Patients were divided into two groups on the basis of their LH responses to LH-RH. In Group A (seven patients) the response at 92 h was greater than at 44 h as in the normal subjects, but in Group B (ten patients) the response at 44 h was greater than at 92 h. Basal serum hormone values were similar in the two groups except for androgens and oestrone, which were significantly (P less than 0.01) higher in Group B patients. There was a negative correlation between the basal androgen and oestrone concentrations and the LH and FSH amplifications at 92 h in all PCO patients. The ratios of the basal concentrations of LH to FSH and the ratios of the highest levels of each achieved during the basal LH-RH test, were significantly higher in the two groups of patients when compared to controls (P less than 0.01). The test is of value in predicting the subsequent responsiveness to clomiphene. All patients in Group A showed evidence of ovulation following treatment with 100 mg clomiphene for 5 days, but only one of Group B responded in this way.
对17例诊断为多囊卵巢（PCO）疾病的患者，在给予2.5mg苯甲酸雌二醇治疗前、治疗后44小时和92小时进行了促黄体生成素释放激素（LH - RH）试验。将这些反应与10名正常受试者在月经周期卵泡早期（第4 - 6天）进行的相同试验结果进行比较。根据患者对LH - RH的LH反应将患者分为两组。A组（7例患者）92小时的反应与正常受试者一样大于44小时的反应，但B组（10例患者）44小时的反应大于92小时的反应。除雄激素和雌酮外，两组的基础血清激素值相似，B组患者的雄激素和雌酮显著（P＜0.01）更高。在所有PCO患者中，基础雄激素和雌酮浓度与92小时时LH和FSH的增幅呈负相关。与对照组相比，两组患者基础LH与FSH的比值以及基础LH - RH试验期间各自达到的最高水平的比值均显著更高（P＜0.01）。该试验对预测随后对克罗米芬的反应有价值。A组所有患者在接受100mg克罗米芬治疗5天后均有排卵迹象，但B组只有1例有此反应。
