The Jackson Laboratory, Bar Harbor Maine, 04609, USA.
Nucleic Acids Res. 2023 Jan 6;51(D1):D1067-D1074. doi: 10.1093/nar/gkac1007.
The Mouse Phenome Database (MPD; https://phenome.jax.org; RRID:SCR_003212), supported by the US National Institutes of Health, is a Biomedical Data Repository listed in the Trans-NIH Biomedical Informatics Coordinating Committee registry. As an increasingly FAIR-compliant and TRUST-worthy data repository, MPD accepts phenotype and genotype data from mouse experiments and curates, organizes, integrates, archives, and distributes those data using community standards. Data are accompanied by rich metadata, including widely used ontologies and detailed protocols. Data are from all over the world and represent genetic, behavioral, morphological, and physiological disease-related characteristics in mice at baseline or those exposed to drugs or other treatments. MPD houses data from over 6000 strains and populations, representing many reproducible strain types and heterogenous populations such as the Diversity Outbred where each mouse is unique but can be genotyped throughout the genome. A suite of analysis tools is available to aggregate, visualize, and analyze these data within and across studies and populations in an increasingly traceable and reproducible manner. We have refined existing resources and developed new tools to continue to provide users with access to consistent, high-quality data that has translational relevance in a modernized infrastructure that enables interaction with a suite of bioinformatics analytic and data services.
小鼠表型数据库（MPD；https://phenome.jax.org；RRID:SCR_003212）由美国国立卫生研究院支持，是一个生物医学数据资源库，被列入跨 NIH 生物医学信息协调委员会注册目录。作为一个日益符合 FAIR 原则和值得信赖的数据资源库，MPD 接受来自小鼠实验的表型和基因型数据，并使用社区标准对其进行编目、组织、整合、存档和分发。数据附有丰富的元数据，包括广泛使用的本体论和详细的方案。数据来自世界各地，代表了基线时或暴露于药物或其他治疗后的小鼠的遗传、行为、形态和生理疾病相关特征。MPD 拥有超过 6000 个品系和种群的数据，代表了许多可重复的品系类型和异质种群，如多样性杂交群体（Diversity Outbred），其中每只小鼠都是独一无二的，但可以对整个基因组进行基因分型。一系列分析工具可用于在研究和种群内以及跨研究和种群以越来越可追踪和可重复的方式对这些数据进行聚合、可视化和分析。我们已经改进了现有资源并开发了新工具，以便继续为用户提供一致的高质量数据，这些数据在现代化的基础设施中具有转化相关性，可与一系列生物信息学分析和数据服务进行交互。
