叶下珠变种中的头状烷型 C 二萜。
Cephalotane-type C diterpenoids from var. .
机构信息
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Research Units of Discovery of New Drug Lead Molecules, Chinese Academy of Medical Sciences, Shanghai 201203, China.
出版信息
Org Biomol Chem. 2022 Nov 23;20(45):9000-9009. doi: 10.1039/d2ob01748b.
Seventeen new cephalotane-type diterpenoids, fortalides A-Q (1-17), along with five known analogues, were isolated from the seeds of var. . Their structures were determined by extensive spectroscopic methods, as well as electronic circular dichroism (ECD) and X-ray crystallographic data analyses. Some isolates exhibited unusual structural features that were first found in cephalotane-type diterpenoids, such as the occurrence of the 7-oxabicyclo[4.1.1]octane moiety in 14 and 15 and the -arrangement of 3-OH and Me-19 in 9. Besides, the antiplasmodial activity of these compounds was evaluated in this study.
从 var. 的种子中分离得到了 17 种新的cephalotane 型二萜类化合物，分别命名为 fortalides A-Q（1-17），此外还有 5 种已知类似物。通过广泛的光谱方法以及电子圆二色性（ECD）和 X 射线晶体学数据分析确定了它们的结构。一些分离物具有不寻常的结构特征，这些特征是首次在 cephalotane 型二萜类化合物中发现的，例如在 14 和 15 中出现的 7-氧杂双环[4.1.1]辛烷部分，以及在 9 中 3-OH 和 Me-19 的 - 排列。此外，本研究还评价了这些化合物的抗疟活性。
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