Jiang Chunyu, Han Zimeng, Sun Wen, Tan Jiayi, Gao Guiwen, Wang Xuan, Hua Huiming, Zhao Rui, Han Tong
Department of Pharmaceutical Engineering, College of Life Science & Technology, Heilongjiang Bayi Agricultural University, 5 Xinfeng Road, Daqing, 163319, PR China.
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, And School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Phytochemistry. 2024 Jan;217:113924. doi: 10.1016/j.phytochem.2023.113924. Epub 2023 Nov 11.
Four undescribed naturally diterpenolignans, and two cephalotane diterpenoids, along with seven known compounds, including two pairs of enantiomers, were isolated from the twigs and leaves of Cephalotaxus oliveri Mast. Their structures were elucidated via spectroscopic data interpretation, chiral-phase HPLC analysis, NMR calculations, and electronic circular dichroism analysis. All the isolated compounds were evaluated for their cytotoxic activities against three kinds of human tumor cell lines. Among them, compound 8 exhibited the most potent activities against MCF-7, HepG2 and A549 cell lines with IC values of 2.83, 4.75 and 2.77 μM, respectively.
从鄂西粗榧（Cephalotaxus oliveri Mast.）的枝叶中分离得到了4个未被描述的天然二萜木脂素、2个三尖杉烷二萜类化合物以及7个已知化合物，其中包括两对对映体。通过光谱数据解析、手性相高效液相色谱分析、核磁共振计算和电子圆二色性分析对它们的结构进行了阐明。对所有分离得到的化合物针对三种人类肿瘤细胞系的细胞毒性活性进行了评估。其中，化合物8对MCF-7、HepG2和A549细胞系表现出最强的活性，其IC值分别为2.83、4.75和2.77 μM。
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