神经退行性变中的 X 因素。

Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.

J Exp Med. 2022 Dec 5;219(12). doi: 10.1084/jem.20211488. Epub 2022 Nov 4.

Given the aging population, it is important to better understand neurodegeneration in aging healthy people and to address the increasing incidence of neurodegenerative diseases. It is imperative to apply novel strategies to identify neuroprotective therapeutics. The study of sex differences in neurodegeneration can reveal new candidate treatment targets tailored for women and men. Sex chromosome effects on neurodegeneration remain understudied and represent a promising frontier for discovery. Here, we will review sex differences in neurodegeneration, focusing on the study of sex chromosome effects in the context of declining levels of sex hormones during aging.

鉴于人口老龄化，了解衰老健康人群中的神经退行性变以及解决神经退行性疾病发病率不断上升的问题非常重要。应用新策略来确定神经保护疗法势在必行。研究神经退行性变中的性别差异可以揭示针对女性和男性的新候选治疗靶点。性染色体对神经退行性变的影响仍研究不足，是一个很有前途的发现领域。在这里，我们将回顾神经退行性变中的性别差异，重点研究衰老过程中性激素水平下降背景下性染色体效应。