正常人各类组织及血浆IgA缺乏患者空肠中IgA 1和IgA 2浆细胞的分布
Distribution of IgA 1 and IgA 2 plasma cells in various normal human tissues and in the jejunum of plasma IgA-deficient patients.
作者信息
André C, André F, Fargier C
出版信息
Clin Exp Immunol. 1978 Aug;33(2):327-31.
Abstract
The distribution of IgA 1 and IgA 2 plasma cells was studied in normal human tissues. IgA 2 is a minor constituent in peripheral lymph nodes as well as in serum and in bone marrow plasma cells. An increased proportion of IgA 2 plasma cells was observed in gastric and intestinal mucosa, as well as in bronchial mucosa and salivary and mammary glands. Tonsils and mesenteric lymph nodes exhibit values intermediate between those of central and peripheral lymphoid systems. In patients with plasma IgA-deficiency, IgA 2 is the predominant intestinal IgA plasma cells. This may explain the frequent association of an asymptomatic condition and plasma IgA deficiency.
摘要
对正常人组织中IgA 1和IgA 2浆细胞的分布进行了研究。IgA 2在外周淋巴结、血清以及骨髓浆细胞中是次要成分。在胃和肠黏膜以及支气管黏膜、唾液腺和乳腺中观察到IgA 2浆细胞的比例增加。扁桃体和肠系膜淋巴结的值介于中枢和外周淋巴系统之间。在血浆IgA缺乏的患者中，IgA 2是肠道中主要的IgA浆细胞。这可能解释了无症状状态与血浆IgA缺乏之间的频繁关联。
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