针对传染病和儿童癌症的免疫接种。
Immunizations against infectious diseases and childhood cancers.
作者信息
Kneale G W, Stewart A M, Wilson L M
出版信息
Cancer Immunol Immunother. 1986;21(2):129-32. doi: 10.1007/BF00199860.
Abstract
A study based upon an unusually large series of childhood cancers and matched controls found a significant deficit of case/control pairs in which the cancer case had fewer immunizations against infectious diseases than the matched control. All types of immunizations and cancers were affected but the case/control differences were more pronounced for older cases with late immunizations than for younger cases with early immunizations, and more pronounced for solid tumours than leukaemia. Therefore there may be immune system responses to immunizations (or simulated infections) which make it difficult for small clones of cancer cells to enlarge and are more successful in preventing localised tumours in adolescents than childhood leukaemias.
摘要
一项基于一系列数量异常庞大的儿童癌症病例及匹配对照的研究发现，在癌症病例接种的传染病疫苗比匹配对照少的病例/对照对中，存在显著不足。所有类型的疫苗接种和癌症均受到影响，但病例/对照差异在接种疫苗较晚的大龄病例中比在接种疫苗较早的低龄病例中更为明显，在实体瘤中比在白血病中更为明显。因此，可能存在针对疫苗接种（或模拟感染）的免疫系统反应，这使得癌细胞小克隆难以扩大，并且在预防青少年局部肿瘤方面比儿童白血病更成功。
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