Department of Reproductive Immunology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China; Shanghai Key Laboratory of Maternal and Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology,Shanghai First Maternity and Infant Hospital, School of Medicine,Tongji University, Shanghai 200092, China.
Department of Reproductive Immunology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China; Shanghai Key Laboratory of Maternal and Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology,Shanghai First Maternity and Infant Hospital, School of Medicine,Tongji University, Shanghai 200092, China.
J Reprod Immunol. 2022 Dec;154:103758. doi: 10.1016/j.jri.2022.103758. Epub 2022 Oct 22.
The role of male factors in recurrent pregnancy loss (RPL) is receiving increased attention since sperm quantity and quality, male genetic mutations, as well as epigenetic modifications, have all been associated with RPL. A growing number of studies have been published on the relationship between male factors and RPL; however, these reports are limited due to small sample sizes, inconsistent inclusion criteria, and detection methods. Herein, we investigate the effects of several male factors on RPL from a genetic and non-genetic perspective to aid clinicians in determining the etiology and optimal treatment strategy for patients with RPL.
男性因素在复发性妊娠丢失（RPL）中的作用越来越受到关注，因为精子数量和质量、男性基因突变以及表观遗传修饰都与 RPL 有关。越来越多的研究已经发表了关于男性因素与 RPL 之间关系的报道；然而，由于样本量小、纳入标准不一致和检测方法不同，这些报道受到了限制。在此，我们从遗传和非遗传的角度研究了几个男性因素对 RPL 的影响，以帮助临床医生确定 RPL 患者的病因和最佳治疗策略。
