Mu Fangxiang, Huo Huyan, Wang Mei, Wang Fang
Department of Reproductive Medicine Lanzhou University Second Hospital Lanzhou China.
Food Sci Nutr. 2023 Jun 1;11(8):4460-4471. doi: 10.1002/fsn3.3464. eCollection 2023 Aug.
Recurrent miscarriage (RM) affects approximately 1%-5% of couples worldwide. Due to its complicated etiologies, the treatments for RM also vary greatly, including surgery for anatomic factors such as septate uterus and uterine adhesions, thyroid modulation drugs for hyperthyroidism and hypothyroidism, and aspirin and low molecular weight heparin for antiphospholipid syndrome. However, these treatment modalities are still insufficient to solve RM. Omega-3 fatty acids are reported to modulate the dysregulation of immune cells, oxidative stress, endocrine disorders, inflammation, etc., which are closely associated with the pathogenesis of RM. However, there is a lack of a systematic description of the involvement of omega-3 fatty acids in treating RM, and the underlying mechanisms are also not clear. In this review, we sought to determine the potential mechanisms that are highly associated with the pathogenesis of RM and the regulation of omega-3 fatty acids on these mechanisms. In addition, we also highlighted the direct and indirect clinical evidence of omega-3 fatty acid supplements to treat RM, which might encourage the application of omega-3 fatty acids to treat RM, thus improving pregnancy outcomes.
复发性流产（RM）影响着全球约1%-5%的夫妇。由于其病因复杂，RM的治疗方法也差异很大，包括针对如纵隔子宫和子宫粘连等解剖因素的手术、针对甲状腺功能亢进和减退的甲状腺调节药物，以及针对抗磷脂综合征的阿司匹林和低分子量肝素。然而，这些治疗方式仍不足以解决RM问题。据报道，ω-3脂肪酸可调节免疫细胞失调、氧化应激、内分泌紊乱、炎症等，这些都与RM的发病机制密切相关。然而，目前缺乏关于ω-3脂肪酸在治疗RM中作用的系统描述，其潜在机制也尚不清楚。在本综述中，我们试图确定与RM发病机制高度相关的潜在机制以及ω-3脂肪酸对这些机制的调节作用。此外，我们还强调了补充ω-3脂肪酸治疗RM的直接和间接临床证据，这可能会促使ω-3脂肪酸在治疗RM中的应用，从而改善妊娠结局。
