端粒 ALT 中 R&D-loop 部门的 TERRA 和 RAD51AP1。

TERRA and RAD51AP1 at the R&D-loop department of ALT telomeres.

机构信息

Genetic and Epigenetic Alterations of Genomes, Telomere Research Group, de Duve Institute, UCLouvain, Brussels, Belgium.

出版信息

Mol Cell. 2022 Nov 3;82(21):3963-3965. doi: 10.1016/j.molcel.2022.10.006.

DOI:10.1016/j.molcel.2022.10.006

PMID:36332602

Abstract

In this issue of Molecular Cell, Kaminski et al. and Yadav et al. demonstrate that RAD51AP1 and TERRA non-coding RNA positively regulate the alternative mechanism of telomere maintenance by promoting D-loop formation and chromatin-directed mechanisms to suppress transcription-collision events during ALT telomere synthesis.

摘要

在本期《分子细胞》中，Kaminski 等人和 Yadav 等人表明，RAD51AP1 和 TERRA 非编码 RNA 通过促进 D 环形成和染色质导向机制来抑制 ALT 端粒合成过程中的转录碰撞事件，从而正向调节端粒维持的替代机制。