Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.
Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Cancer Cell. 2022 Nov 14;40(11):1266-1268. doi: 10.1016/j.ccell.2022.10.010. Epub 2022 Nov 3.
Understanding lineage plasticity in prostate cancer cells is crucial to overcoming disease progression and therapeutic resistance. In this issue of Cancer Cell, Han et al. demonstrate that Foxa2 promotes luminal-to-neuroendocrine differentiation and that it also upregulates Kit expression in neuroendocrine cells. KIT signaling inhibition represents a promising therapeutic strategy in neuroendocrine prostate cancer.
了解前列腺癌细胞谱系可塑性对于克服疾病进展和治疗耐药性至关重要。在本期《癌细胞》杂志中，Han 等人表明 Foxa2 促进了腔细胞向神经内分泌分化，并且它还上调了神经内分泌细胞中的 Kit 表达。KIT 信号抑制代表了神经内分泌前列腺癌的一种有前途的治疗策略。
