Department of Anesthesiology, Health Science Center, Stony Brook University, Stony Brook, NY 11794, USA.
Department of Anesthesiology, Health Science Center, Stony Brook University, Stony Brook, NY 11794, USA.
Pharmacol Ther. 2022 Dec;240:108302. doi: 10.1016/j.pharmthera.2022.108302. Epub 2022 Nov 1.
TRPM7, a divalent cation-selective channel with kinase domains, has been widely reported to potentially affect cancers. In this study, we conducted multiple bioinformatic analyses based on open databases and reviewed articles that provided evidence for the effects of TRPM7 on cancers. The purposes of this paper are 1) to provide a pan-cancer overview of TRPM7 in cancers; 2) to summarize evidence of TRPM7 effects on cancers; 3) to identify potential future studies of TRPM7 in cancer. Bioinformatics analysis revealed that no cancer-related TRPM7 mutation was found. TRPM7 is aberrantly expressed in most cancer types but the cancer-noncancer expression pattern varies across cancer types. TRPM7 was not associated with survival, TMB, or cancer stemness in most cancer types. TRPM7 affected drug sensitivity and tumor immunity in some cancer types. The in vitro evidence, preclinical in vivo evidence, and clinical evidence for TRPM7 effects on cancers as well as TRPM7 kinase substrate and TRPM7-targeting drugs associated with cancers were summarized to facilitate comparison. We matched the bioinformatics evidence to literature evidence, thereby unveiling potential avenues for future investigation of TRPM7 in cancers. We believe that this paper will help orient research toward important and relevant aspects of the role of TRPM7 in cancers.
TRPM7 是一种具有激酶结构域的二价阳离子选择性通道，广泛报道其可能影响癌症。在这项研究中，我们基于公开数据库进行了多项生物信息学分析，并回顾了提供 TRPM7 对癌症影响证据的文章。本文的目的是：1）提供癌症中 TRPM7 的泛癌概述；2）总结 TRPM7 对癌症影响的证据；3）确定 TRPM7 在癌症中未来研究的潜力。生物信息学分析显示，未发现与癌症相关的 TRPM7 突变。TRPM7 在大多数癌症类型中异常表达，但癌症-非癌症表达模式在不同癌症类型之间存在差异。在大多数癌症类型中，TRPM7 与生存、TMB 或癌症干性无关。TRPM7 影响某些癌症类型的药物敏感性和肿瘤免疫。本文总结了 TRPM7 对癌症影响的体外证据、临床前体内证据和临床证据，以及与癌症相关的 TRPM7 激酶底物和 TRPM7 靶向药物，以方便比较。我们将生物信息学证据与文献证据相匹配，从而揭示了未来研究 TRPM7 在癌症中的潜在途径。我们相信，本文将有助于将研究方向导向 TRPM7 在癌症中作用的重要和相关方面。
