脊柱关节炎的环境风险因素。

Environmental Risks for Spondyloarthropathies.

机构信息

Division of Rheumatology, Department of Internal Medicine, John P. and Kathrine G. McGovern School of Medicine at The University of Texas Health Science Center at Houston, 6431 Fannin MSB 5.270, Houston, TX 77030, USA.

出版信息

Rheum Dis Clin North Am. 2022 Nov;48(4):813-826. doi: 10.1016/j.rdc.2022.06.004.

DOI:10.1016/j.rdc.2022.06.004

PMID:36332997

Abstract

Spondyloarthropathies, also known as spondyloarthritis, encompasses a spectrum of diseases classified by it's axial and peripheral musculoskeletal manifestations. Extra-articular features are common in SpA making these systemic rheumatologic diseases involve the skin, eye, gut, and other organ systems.Research has identified risk factors for the development of spondyloarthritis, particularly regarding genetic susceptibility and the strong association with HLA-B27. Multiple studies have elucidated clinical risk factors associated with SpA disease activity and severity. In this review, we aim to explore the environmental risk factors for spondyloarthritis.

摘要

脊柱关节炎，又称脊柱关节病，包含了一系列以中轴和外周骨骼肌肉表现为特征的疾病。脊柱关节炎的关节外表现很常见，使这些全身性风湿性疾病累及皮肤、眼睛、肠道和其他器官系统。研究已经确定了脊柱关节炎发展的风险因素，特别是遗传易感性和与 HLA-B27 的强烈关联。多项研究阐明了与脊柱关节炎疾病活动度和严重程度相关的临床风险因素。在这篇综述中，我们旨在探讨脊柱关节炎的环境风险因素。