Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital of Sichuan University, 610041, Chengdu, China.
Psychoradiology Research Unit of the Chinese Academy of Medical Sciences (2018RU011), West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Commun Biol. 2022 Nov 4;5(1):1184. doi: 10.1038/s42003-022-04115-z.
A precise understanding of amygdala-centered subtle networks may help refine neurocircuitry models of obsessive-compulsive disorder (OCD). We applied connectivity-based parcellation methodology to segment the amygdala based on resting-state fMRI data of 92 medication-free OCD patients without comorbidity and 90 matched healthy controls (HC). The amygdala was parcellated into two subregions corresponding to basolateral amygdala (BLA) and centromedial amygdala (CMA). Amygdala subregional functional connectivity (FC) maps were generated and group differences were evaluated with diagnosis-by-subregion flexible factorial ANOVA. We found significant diagnosis × subregion FC interactions in insula, supplementary motor area (SMA), midcingulate cortex (MCC), superior temporal gyrus (STG) and postcentral gyrus (PCG). In HC, the BLA demonstrated stronger connectivity with above regions compared to CMA, whereas in OCD, the connectivity pattern reversed to stronger CMA connectivity comparing to BLA. Relative to HC, OCD patients exhibited hypoconnectivity between left BLA and left insula, and hyperconnectivity between right CMA and SMA, MCC, insula, STG, and PCG. Moreover, OCD patients showed reduced volume of left BLA and right CMA compared to HC. Our findings characterized disorganized functional architecture of amygdala subregional networks in accordance with structural defects, providing direct evidence regarding the specific role of amygdala subregions in the neurocircuitry models of OCD.
对以杏仁核为中心的微妙网络的精确理解可能有助于完善强迫症（OCD）的神经回路模型。我们应用基于连接的分割方法，根据 92 名无共病的未用药 OCD 患者和 90 名匹配的健康对照者的静息态 fMRI 数据，对杏仁核进行分割。将杏仁核分为两个亚区，对应于基底外侧杏仁核（BLA）和中央内侧杏仁核（CMA）。生成杏仁核亚区功能连接（FC）图，并通过诊断-亚区灵活因子方差分析评估组间差异。我们发现岛叶、补充运动区（SMA）、中央扣带皮层（MCC）、颞上回（STG）和后中央回（PCG）存在显著的诊断×亚区 FC 相互作用。在 HC 中，与 CMA 相比，BLA 与上述区域的连接更强，而在 OCD 中，与 BLA 相比，CMA 的连接模式发生了逆转，更强。与 HC 相比，OCD 患者的左 BLA 与左岛叶之间的连接减弱，右 CMA 与 SMA、MCC、岛叶、STG 和 PCG 之间的连接增强。此外，与 HC 相比，OCD 患者的左 BLA 和右 CMA 体积减小。我们的发现描绘了杏仁核亚区网络的功能结构紊乱，与结构缺陷一致，为杏仁核亚区在 OCD 的神经回路模型中的特定作用提供了直接证据。
