Zhang Mengzhe, Gao Xinyu, Yang Zhengui, Niu Xiaoyu, Wang Weijian, Han Shaoqiang, Wei Yarui, Cheng Jingliang, Zhang Yong
Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
J Neurosci Res. 2023 Feb;101(2):232-244. doi: 10.1002/jnr.25141. Epub 2022 Nov 5.
Tobacco smoking and overweight lead to adverse health effects, which remain an important public health problem worldwide. Researches indicate overlapping pathophysiology may contribute to tobacco use disorder (TUD) and overweight, but the neurobiological interaction mechanism between the two factors is still unclear. This study used a mixed sample design, including the following four groups: (i) overweight long-term smokers (n = 24, age = 31.80 ± 5.70, cigarettes/day = 20.50 ± 7.89); (ii) normal weight smokers (n = 28, age = 31.29 ± 5.56, cigarettes/day = 16.11 ± 8.35); (iii) overweight nonsmokers (n = 19, age = 33.05 ± 5.60), and (iv) normal weight nonsmokers (n = 28, age = 31.68 ± 6.57), a total of 99 male subjects. All subjects underwent T1-weighted high-resolution MRI. We used voxel-based morphometry to compare gray matter volume (GMV) among the four groups. Then, JuSpace toolbox was used for cross-modal correlations of MRI-based modalities with nuclear imaging derived estimates, to examine specific neurotransmitter system changes underlying the two factors. Our results illustrate a significant antagonistic interaction between TUD and weight status in left dorsolateral prefrontal cortex (DLPFC), and a quadratic effect of BMI on DLPFC GMV. For main effect of TUD, long-term smokers were associated with greater GMV in bilateral OFC compared with nonsmokers irrespective of weight status, and such alteration is negatively associated with pack-year and FTND scores. Furthermore, we also found GMV changes related to TUD and overweight are associated with μ-opioid receptor system and TUD-related GMV alterations are associated with noradrenaline transporter maps. This study sheds light on novel multimodal neuromechanistic about the relationship between TUD and overweight, which possibly provides hints into future treatment for the special population of comorbid TUD and overweight.
吸烟和超重会对健康产生不良影响，这在全球范围内仍是一个重要的公共卫生问题。研究表明，重叠的病理生理学可能导致烟草使用障碍（TUD）和超重，但这两个因素之间的神经生物学相互作用机制仍不清楚。本研究采用混合样本设计，包括以下四组：（i）超重长期吸烟者（n = 24，年龄 = 31.80 ± 5.70，每日吸烟量 = 20.50 ± 7.89）；（ii）正常体重吸烟者（n = 28，年龄 = 31.29 ± 5.56，每日吸烟量 = 16.11 ± 8.35）；（iii）超重非吸烟者（n = 19，年龄 = 33.05 ± 5.60），以及（iv）正常体重非吸烟者（n = 28，年龄 = 31.68 ± 6.57），共99名男性受试者。所有受试者均接受了T1加权高分辨率MRI检查。我们使用基于体素的形态测量法比较四组之间的灰质体积（GMV）。然后，使用JuSpace工具箱对基于MRI的模态与核成像衍生估计值进行跨模态相关性分析，以检查这两个因素背后特定神经递质系统的变化。我们的结果表明，在左侧背外侧前额叶皮层（DLPFC）中，TUD与体重状况之间存在显著的拮抗相互作用，且BMI对DLPFC的GMV有二次效应。对于TUD的主效应，无论体重状况如何，长期吸烟者与非吸烟者相比，双侧眶额皮质（OFC）的GMV更大，且这种改变与吸烟包年数和烟草依赖评估量表（FTND）得分呈负相关。此外，我们还发现与TUD和超重相关的GMV变化与μ-阿片受体系统有关，且与TUD相关的GMV改变与去甲肾上腺素转运体图谱有关。本研究揭示了关于TUD与超重之间关系的新型多模态神经机制，这可能为未来治疗TUD和超重合并症的特殊人群提供线索。
