Zhang Mengzhe, Gao Xinyu, Yang Zhengui, Niu Xiaoyu, Chen Jingli, Wei Yarui, Wang Weijian, Han Shaoqiang, Cheng Jingliang, Zhang Yong
Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China.
Front Psychiatry. 2022 Jun 6;13:857479. doi: 10.3389/fpsyt.2022.857479. eCollection 2022.
Tobacco smoking and being overweight could lead to adverse health effects, which remain an important public health problem worldwide. Research indicates that overlapping pathophysiology may contribute to tobacco addiction and being overweight, but the neurobiological interaction mechanism between the two factors is still unclear.
The current study used a mixed sample design, including the following four groups: (i) overweight long-term smokers ( = 24); (ii) normal-weight smokers ( = 28); (iii) overweight non-smokers ( = 19), and (iv) normal-weight non-smokers ( = 28), for a total of 89 male subjects. All subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI). Regional homogeneity (ReHo) was used to compare internal cerebral activity among the four groups. Interaction effects between tobacco addiction and weight status on ReHo were detected using a two-way analysis of variance, correcting for age, years of education, and head motion.
A significant interaction effect between tobacco addiction and weight status is shown in right superior frontal gyrus. Correlation analyses show that the strengthened ReHo value in the right superior frontal gyrus is positively associated with pack-year. Besides, the main effect of tobacco addiction is specially observed in the occipital lobe and cerebellum posterior lobe. As for the main effect of weight status, the right lentiform nucleus, left postcentral gyrus, and brain regions involved in default mode network (DMN) survived.
These results shed light on an antagonistic interaction on brain ReHo between tobacco addiction and weight status in the right superior frontal gyrus, which may be a clinical neuro-marker of comorbid tobacco addiction and overweight. Our findings may provide a potential target to develop effective treatments for the unique population of comorbid tobacco addiction and overweight people.
吸烟和超重会对健康产生不良影响，这在全球范围内仍是一个重要的公共卫生问题。研究表明，重叠的病理生理学可能导致烟草成瘾和超重，但这两个因素之间的神经生物学相互作用机制仍不清楚。
本研究采用混合样本设计，包括以下四组：（i）超重长期吸烟者（n = 24）；（ii）正常体重吸烟者（n = 28）；（iii）超重非吸烟者（n = 19），以及（iv）正常体重非吸烟者（n = 28），共有89名男性受试者。所有受试者均接受静息态功能磁共振成像（rs-fMRI）。采用局部一致性（ReHo）比较四组之间的大脑内部活动。使用双向方差分析检测烟草成瘾和体重状况对ReHo的交互作用，并对年龄、受教育年限和头部运动进行校正。
右上额回显示出烟草成瘾和体重状况之间存在显著的交互作用。相关性分析表明，右上额回中增强的ReHo值与吸烟包年数呈正相关。此外，在枕叶和小脑后叶特别观察到烟草成瘾的主效应。至于体重状况的主效应，右侧豆状核、左侧中央后回以及默认模式网络（DMN）涉及的脑区有显著差异。
这些结果揭示了右上额回中烟草成瘾和体重状况对大脑ReHo的拮抗作用，这可能是烟草成瘾和超重共病的临床神经标志物。我们的研究结果可能为开发针对烟草成瘾和超重共病这一独特人群的有效治疗方法提供潜在靶点。
