School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Whitlam Orthopaedic Research Centre, Ingham Institute for Applied Medical Research, Sydney, Australia.
ANZ J Surg. 2022 Dec;92(12):3311-3318. doi: 10.1111/ans.18134. Epub 2022 Nov 5.
Given the cost differential between surgical and non-surgical management of distal radius fractures, we aimed to evaluate the cost-effectiveness of surgical compared with non-surgical treatment of distal radius fractures in a cohort of older patients.
This evaluation was conducted alongside the combined randomized and observational study of surgery for fractures of the distal radius in the elderly (CROSSFIRE) trial (ACTRN 12616000969460) which compared surgical (open reduction and internal fixation using volar-locking plate (VLP) fixation) and non-surgical (closed fracture reduction and cast immobilization (CR)) treatment for displaced distal radius fractures in patients ≥60 years. Cost-effectiveness was assessed from the perspective of the public hospital funder. Hospital records from a sub-sample of participants were used to estimate costs. Outcomes were patient-reported wrist pain and function questionnaire (PRWE) scores and quality adjusted life years (QALYs) calculated using the EuroQoL five-dimension five-level tool (EQ-5D-5L).
From 166 participants (81 surgical, 85 non-surgical), costs were obtained for 56 (29 surgical, 27 non-surgical). The mean costs for VLP fixation were Australian dollars (AUD) 6668 (95% CI $4857 to $8479) compared to AUD 3343 (95% CI $1304 to $5381) for CR. The incremental cost-effectiveness ratios (ICER) to achieve a 1-point improvement in the PRWE were AUD 375, AUD 1736 and AUD 1126 at 3, 12 and 24 months for VLP compared with CR. At 12 months, the cost effectiveness was dominated by CR (lower cost and better QoL) whereas at 24 months, the incremental cost per QALY gained by VLP was AUD 1 946 127.
In the treatment of distal radius fractures in patients ≥60 years, VLP fixation was not cost-effective compared with CR from the perspective of hospital funders.
鉴于手术与非手术治疗桡骨远端骨折的成本差异,我们旨在评估在老年患者队列中手术与非手术治疗桡骨远端骨折的成本效益。
本评估是在老年人桡骨远端骨折的联合随机和观察性研究(CROSSFIRE)试验(ACTRN 12616000969460)的基础上进行的,该试验比较了手术(掌侧锁定钢板(VLP)固定的切开复位内固定)和非手术(闭合复位和石膏固定(CR))治疗≥60 岁患者桡骨远端移位骨折的方法。从公立医院资金提供者的角度评估了成本效益。从参与者的子样本中获取了医院记录,以估算成本。结果为患者报告的腕关节疼痛和功能问卷(PRWE)评分以及使用欧洲五维健康量表(EQ-5D-5L)计算的质量调整生命年(QALYs)。
在 166 名参与者(81 例手术,85 例非手术)中,有 56 名(29 例手术,27 例非手术)获得了成本数据。VLP 固定的平均费用为澳元(AUD)6668(95%CI,4857 至 8479),而 CR 的费用为 AUD3343(95%CI,1304 至 5381)。与 CR 相比,VLP 在 3、12 和 24 个月时 PRWE 提高 1 分的增量成本效益比(ICER)分别为 AUD375、AUD1736 和 AUD1126。在 12 个月时,CR 的成本效益更优(成本更低,生活质量更高),而在 24 个月时,VLP 每增加一个 QALY 的增量成本为 AUD1946127。
从医院资金提供者的角度来看,在治疗≥60 岁患者的桡骨远端骨折时,与 CR 相比,VLP 固定不具有成本效益。