Lami Raphaël, Urios Laurent, Molmeret Maëlle, Grimaud Régis
Sorbonne Université, USR3579, LBBM, Observatoire Océanologique, Banyuls-sur-Mer, France.
Centre National de la Recherche Scientifique, USR 3579, LBBM, Observatoire Océanologique, Banyuls-sur-Mer, France.
Crit Rev Microbiol. 2023 Nov;49(6):786-804. doi: 10.1080/1040841X.2022.2142089. Epub 2022 Nov 5.
Our environment is heavily contaminated by anthropogenic compounds, and this issue constitutes a significant threat to all life forms, including biofilm-forming microorganisms. Cell-cell interactions shape microbial community structures and functions, and pollutants that affect intercellular communications impact biofilm functions and ecological roles. There is a growing interest in environmental science fields for evaluating how anthropogenic pollutants impact cell-cell interactions. In this review, we synthesize existing literature that evaluates the impacts of quorum sensing (QS), which is a widespread density-dependent communication system occurring within many bacterial groups forming biofilms. First, we examine the perturbating effects of environmental contaminants on QS circuits; and our findings reveal that QS is an essential yet underexplored mechanism affected by pollutants. Second, our work highlights that QS is an unsuspected and key resistance mechanism that assists bacteria in dealing with environmental contamination (caused by metals or organic pollutants) and that favors bacterial growth in unfavourable environments. We emphasize the value of considering QS a critical mechanism for monitoring microbial responses in ecotoxicology. Ultimately, we determine that QS circuits constitute promising targets for innovative biotechnological approaches with major perspectives for applications in the field of environmental science.
我们的环境受到人为化合物的严重污染，这一问题对包括形成生物膜的微生物在内的所有生命形式都构成了重大威胁。细胞间相互作用塑造了微生物群落的结构和功能，而影响细胞间通讯的污染物会影响生物膜的功能和生态作用。环境科学领域越来越关注评估人为污染物如何影响细胞间相互作用。在这篇综述中，我们综合了现有文献，这些文献评估了群体感应（QS）的影响，群体感应是一种广泛存在于许多形成生物膜的细菌群体中的密度依赖性通讯系统。首先，我们研究了环境污染物对QS回路的干扰作用；我们的研究结果表明，QS是一种受污染物影响的重要但尚未充分探索的机制。其次，我们的工作强调，QS是一种意想不到的关键抗性机制，它帮助细菌应对环境污染（由金属或有机污染物引起），并有利于细菌在不利环境中生长。我们强调将QS视为生态毒理学中监测微生物反应的关键机制的价值。最终，我们确定QS回路是创新生物技术方法的有前景的目标，在环境科学领域有重要的应用前景。
