Department of Surgery, Rush University Medical Center, Rush University, 600 South Paulina Street, Chicago, IL 60612, USA.
Breast Surgery Oncology, Rush University Medical Center, Chicago, IL, USA.
Surg Clin North Am. 2022 Dec;102(6):947-963. doi: 10.1016/j.suc.2022.07.001.
Lobular neoplasia (LN) is a term that describes atypical epithelial lesions originating in the terminal duct-lobular unit (TDLU) of the breast, including atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS). LN is both a risk factor and nonobligate precursor to invasive breast cancer. A diagnosis of LCIS is associated with a 7-to-10-fold increased risk of breast cancer compared with the general population. When classic LN is diagnosed on a core needle biopsy (CNB), the patient may proceed with either increased screening or excisional biopsy of the lesion. Physicians should counsel patients diagnosed with LN on the risk of developing invasive carcinoma and inform them of the current screening and chemoprevention recommendations to reduce risk.
小叶肿瘤（LN）是一个术语，用于描述起源于乳腺终末导管小叶单位（TDLU）的非典型上皮病变，包括非典型小叶增生（ALH）和小叶原位癌（LCIS）。LN 既是乳腺癌的危险因素，也是非必需的前期病变。与普通人群相比，LCIS 的诊断与乳腺癌的风险增加 7 至 10 倍相关。当在核心针活检（CNB）上诊断出经典 LN 时，患者可以选择增加筛查或切除病变活检。医生应就罹患浸润性癌的风险向诊断为 LN 的患者进行咨询，并告知他们目前的筛查和化学预防建议以降低风险。
