Ghasemi Fatemeh, Navab Fatemeh, Rouhani Mohammad Hossein, Amini Pegah, Shokri-Mashhadi Nafiseh
Nutrition and Food Security Research Center and Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Prostaglandins Other Lipid Mediat. 2023 Feb;164:106691. doi: 10.1016/j.prostaglandins.2022.106691. Epub 2022 Nov 3.
The relationship between circulating Lutein and zeaxanthin (L/Z) concentrations, and plasma lipoproteins has been indicated by observational studies. However, the beneficial impact of L/Z administration on dyslipidemia are unclear. This meta-analysis aimed to investigate the effect of oral intake of L/Z on circulating total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), as well as high-density lipoprotein-cholesterol (HDL-C) levels.
We electronically assessed all eligible interventional studies through different electronic databases, including PubMed, Scopus, ISI -Web of Science, and Cochrane library until Jun 2021. After identifying the quality of each included randomized controlled trials, they were evaluated by assessing the risk-difference between treatment and control groups by pooling available data on net change of serum LDL-C, HDL-C, and Cholesterol.
L/Z supplementation has null effect on circulating levels of TC (WMD: -3.82 95% CI: -13.83, 6.18; I-square: 85.2%), and LDL-C (WMD: -4.54; 95% CI: -11.5, 2.48; I-square: 83.9%). In contrast, L/Z treatment could significantly increase HDL-C levels in older adults (WMD: 4.06; 95% CI: 0.64, 7.48; I-square: 50.7%).
L/Z administration could be an effective treatment for improving circulating HDL-C concentration in elderly adults.
观察性研究表明了循环中的叶黄素和玉米黄质（L/Z）浓度与血浆脂蛋白之间的关系。然而，L/Z给药对血脂异常的有益影响尚不清楚。本荟萃分析旨在研究口服L/Z对循环总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）以及高密度脂蛋白胆固醇（HDL-C）水平的影响。
我们通过不同的电子数据库对所有符合条件的干预性研究进行了电子评估，包括PubMed、Scopus、ISI -科学网和Cochrane图书馆，直至2021年6月。在确定每项纳入的随机对照试验的质量后，通过汇总血清LDL-C、HDL-C和胆固醇净变化的可用数据，评估治疗组和对照组之间的风险差异来对其进行评价。
补充L/Z对TC的循环水平（加权均数差：-3.82；95%可信区间：-13.83，6.18；I²：85.2%）和LDL-C（加权均数差：-4.54；95%可信区间：-11.5，2.48；I²：83.9%）没有影响。相比之下，L/Z治疗可显著提高老年人的HDL-C水平（加权均数差：4.06；95%可信区间：0.64，7.48；I²：50.7%）。
给予L/Z可能是改善老年人循环HDL-C浓度的有效治疗方法。
