School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, Rasht, Iran.
Phytother Res. 2019 Jan;33(1):3-12. doi: 10.1002/ptr.6203. Epub 2018 Oct 3.
Despite a history of purslane usage as a herbal treatment for dyslipidemia and hyperglycemia management, existing evidence from clinical trials is controversial. The aim for the current study was to evaluate the efficacy of purslane supplementation on lipid parameters and glycemic status in adult populations. A systematic review was conducted in PubMed, Scopus, ISI Web of Science, and Google Scholar up to January 15, 2018, searching for randomized controlled trials that assessed the impact of purslane on fasting blood glucose (FBG), triglycerides, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Based on the detected heterogeneity between studies, a random- or fixed-effect model was applied in the meta-analysis. The findings from six randomized controlled trials, comprising 352 participants, indicated that purslane can reduce FBG (-4.54 mg/dl, 95% CI [-7.54, -1.53]; I = 0.53%) and triglycerides (-19.16 mg/dl, 95% CI [-38.17, -0.15]; I = 0%) levels. Changes in TC, LDL-C, and HDL-C concentrations did not reach a statistically significant level. Subgroup analysis showed a favorable effects of purslane on FBG, triglycerides, TC, and LDL-C in a subset of studies in which purslane was administered >1.5 g/day. Categorization based on gender showed that purslane was more effective in improving FBG, TC and LDL-C in females compared with males. This systematic review and meta-analysis suggested that the purslane might be effective on the improvement of blood lipid and glucose levels. Further robust studies with sufficient durations and dosages of supplementation are needed to confirm these results.
尽管马齿苋作为治疗血脂异常和高血糖的草药已有应用历史，但现有临床试验证据存在争议。本研究旨在评估马齿苋补充剂对成年人群脂质参数和血糖状态的疗效。系统检索了 PubMed、Scopus、ISI Web of Science 和 Google Scholar 数据库，截至 2018 年 1 月 15 日，收集评估马齿苋对空腹血糖（FBG）、三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）影响的随机对照试验。根据研究间的异质性，采用随机或固定效应模型进行荟萃分析。纳入的 6 项随机对照试验共 352 例参与者，结果表明马齿苋可降低 FBG（-4.54mg/dl，95%CI [-7.54，-1.53]；I²=0.53%）和 TG（-19.16mg/dl，95%CI [-38.17，-0.15]；I²=0%）水平。TC、LDL-C 和 HDL-C 浓度的变化未达到统计学显著水平。亚组分析显示，当马齿苋剂量>1.5g/d 时，其对 FBG、TG、TC 和 LDL-C 的作用更明显。按性别分层分析显示，与男性相比，马齿苋在改善女性 FBG、TC 和 LDL-C 方面更为有效。本系统评价和荟萃分析表明，马齿苋可能对改善血脂和血糖水平有效。需要进一步开展设计良好、足够时长和剂量的研究来证实这些结果。
