Guennouni Morad, Admou Brahim, Elkhoudri Noureddine, Bouchrit Sara, Ait Rami Adil, Bourrahouat Aicha, Krati Khadija, Hilali Abderraouf
Hassan First University of Settat, Higher Institute of Health Sciences of Settat, Laboratory of Health Sciences and Technologies, Settat, Morocco.
Cadi Ayyad University, Biosciences Research Laboratory, Faculty of Medicine and Pharmacy, Laboratory of Immunology, Center of Clinical Research, University Hospital Mohamed VI, Marrakech, Morocco.
Arab J Gastroenterol. 2022 Nov;23(4):246-252. doi: 10.1016/j.ajg.2022.06.009. Epub 2022 Nov 3.
Celiac disease (CD) management is based on a lifelong gluten-free diet (GFD) that affects the quality of life (QoL) of patients with CD. Specific instruments have been used to evaluate this QoL, such as the CD-Questionnaire (CD-Q). This study aimed to translate, validate, and cross-culturally adapt the CD-Q in an Arabic version and then apply it to evaluate the QoL of Moroccan adult patients with CD.
The Moroccan version of the CD-Q (M-CD-Q) was administered to 150 patients with CD, and 112 of them completed it. The reproducibility and reliability of the M-CD-Q were studied by the intraclass coefficient (ICC) and Cronbach's α, respectively. Parametric and nonparametric tests, confirmatory factor analysis, and Spearman correlation were used for the statistical analysis performed by SPSS, and the goodness-of-fit test was determined using SPSS AMOS.
No difficulties were found during the translation and cultural adaptation of the CD-Q. Cronbach's α showed good internal consistency. The retest showed excellent reproducibility (ICC > 0.4). The study of the psychometric properties of the M-CD-Q showed good acceptance, zero ceiling effect, and floor effect. The model fit was good [(root mean square error of approximation = 0.075 (<0.08) and χ2 = 509.04, p < 0.001]. The total scores showed a neutral QoL. This QoL was worse in the worries subscale, which is related to gluten-free products. The GFD did not improve the QoL of the examined samples.
The M-CD-Q is the first reliable and adapted instrument in an Arab country for the evaluation of QoL in patients with CD. CD negatively influences this QoL, especially items related to gluten-free products.
乳糜泻（CD）的管理基于终身无麸质饮食（GFD），这会影响CD患者的生活质量（QoL）。已经使用特定工具来评估这种生活质量，例如乳糜泻问卷（CD-Q）。本研究旨在将CD-Q翻译成阿拉伯语版本，进行验证和跨文化调适，然后应用它来评估摩洛哥成年CD患者的生活质量。
对150例CD患者发放摩洛哥版CD-Q（M-CD-Q），其中112例完成问卷。分别通过组内相关系数（ICC）和克朗巴哈α系数研究M-CD-Q的重现性和可靠性。使用参数检验和非参数检验、验证性因子分析以及Spearman相关性分析进行SPSS统计分析，并使用SPSS AMOS进行拟合优度检验。
在CD-Q的翻译和文化调适过程中未发现困难。克朗巴哈α系数显示出良好的内部一致性。重测显示出出色的重现性（ICC>0.4）。对M-CD-Q心理测量特性的研究显示出良好的可接受性、零天花板效应和地板效应。模型拟合良好[近似均方根误差=0.075（<0.08）且χ2=509.04，p<0.001]。总分显示生活质量为中性。在与无麸质产品相关的担忧子量表中，这种生活质量较差。无麸质饮食并未改善所研究样本的生活质量。
M-CD-Q是阿拉伯国家首个用于评估CD患者生活质量的可靠且经过调适的工具。CD对这种生活质量有负面影响，尤其是与无麸质产品相关的项目。
