Department of Medical, Surgical and Advanced Technologies "G.F. Ingrassia", University of Catania, 95123 Catania, Italy.
Front Biosci (Landmark Ed). 2022 Oct 19;27(10):287. doi: 10.31083/j.fbl2710287.
Microplastics (MPs) and Nanoplastics (NPs) are plastic fragments that spread in the environment and accumulate in the human body, so they have been becoming a worldwide environmental concern because of their potential human health effects. The aim of this systematic review was to investigate the prospective impact of MPs and NPs on the inflammatory process.
Electronic article search was performed on PubMed, Scopus and Web of Science international databases from 1 Jan 2012 to 31 Dec 2021. Screenings of titles, abstracts and full texts were performed according to the Preferred Reporting Item for Systematic Review and Meta-analyses (PRISMA). The methodological quality of the studies was checked by the Toxicological data Reliability Assessment Tool.
Electronic article search identified 125 records, from which 6 , 11 and 2 both and studies were included. Both and studies have showed an increase ofdifferent inflammatory outcomes (Interleukines, Tumor necrosis factor, Chemokines, Interferones, Transcription factors, Growth factors, Oxydoreductase, Proteins and others), thus it seems to confirm the association withthe exposure to microplastics of different types, sizes, exposure times and exposed species.
This systematic review seems to support the relationship between the exposure to MPs and the inflammatory processboth and . Greater caution is needed about the role of NPs because ofa very small number of studies. Additional high-quality studies are warranted to confirm these results, especially the research should be focused on NPs being lacking literature.
微塑料（MPs）和纳米塑料（NPs）是在环境中扩散并在人体内积累的塑料碎片，因此由于它们对人类健康的潜在影响，它们已经成为全球关注的环境问题。本系统评价的目的是研究 MPs 和 NPs 对炎症过程的潜在影响。
从 2012 年 1 月 1 日至 2021 年 12 月 31 日，在 PubMed、Scopus 和 Web of Science 国际数据库中进行了电子文章检索。根据系统评价和荟萃分析的首选报告项目（PRISMA）进行了标题、摘要和全文的筛选。使用毒理学数据可靠性评估工具检查了研究的方法学质量。
电子文章搜索确定了 125 条记录，其中包括 6 项、11 项和 2 项研究。这两项研究都表明不同炎症结局（白细胞介素、肿瘤坏死因子、趋化因子、干扰素、转录因子、生长因子、氧化还原酶、蛋白质等）增加，因此似乎证实了与不同类型、大小、暴露时间和暴露物种的微塑料暴露之间的关联。
本系统评价似乎支持暴露于 MPs 与炎症过程之间的关系，无论是 和 。由于研究数量非常少，因此对 NPs 的作用需要更加谨慎。需要更多高质量的研究来证实这些结果，特别是应侧重于 NPs 的研究，因为这方面的文献非常缺乏。
