Intestinal epithelial cell barrier dysfunction and elevated Angiopoietin-like 4 identified in orally susceptible peanut allergy model.
作者信息
Steinbach Erin C, Smeekens Johanna M, Roy Satyaki, Toyonaga Takahiko, Cornaby Caleb, Perini Layna B, Berglind Ana E, Kulis Michael D, Kim Edwin H, Ferris Martin T, Furey Terrence S, Burks Arvil Wesley, Sheikh Shehzad Z
机构信息
Division of Rheumatology, Allergy, and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
出版信息
Clin Exp Allergy. 2023 Feb;53(2):210-215. doi: 10.1111/cea.14248. Epub 2022 Nov 6.
Abstract
摘要
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Intestinal epithelial cell barrier dysfunction and elevated Angiopoietin-like 4 identified in orally susceptible peanut allergy model.在口服易感性花生过敏模型中发现肠道上皮细胞屏障功能障碍和血管生成素样4升高。
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本文引用的文献
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The role of Sp140 revealed in IgE and mast cell responses in Collaborative Cross mice.Sp140 在协同杂交小鼠 IgE 和肥大细胞反应中的作用。
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Fecal IgA, Antigen Absorption, and Gut Microbiome Composition Are Associated With Food Antigen Sensitization in Genetically Susceptible Mice.粪便 IgA、抗原吸收和肠道微生物组组成与遗传易感小鼠的食物抗原致敏有关。
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Circulating Ara h 6 as a marker of peanut protein absorption in tolerant and allergic humans following ingestion of peanut-containing foods.口服含花生食物后，循环 Ara h 6 可作为人类耐受和过敏个体中花生蛋白吸收的标志物。
Clin Exp Allergy. 2020 Sep;50(9):1093-1102. doi: 10.1111/cea.13706. Epub 2020 Jul 27.
4
ANGPTL4: a multifunctional protein involved in metabolism and vascular homeostasis.血管生成素样蛋白 4：一种参与代谢和血管内环境稳定的多功能蛋白。
Curr Opin Hematol. 2020 May;27(3):206-213. doi: 10.1097/MOH.0000000000000580.
5
Goblet cell associated antigen passages support the induction and maintenance of oral tolerance.杯状细胞相关抗原途径支持诱导和维持口服耐受。
Mucosal Immunol. 2020 Mar;13(2):271-282. doi: 10.1038/s41385-019-0240-7. Epub 2019 Dec 9.
6
Genetic diversity between mouse strains allows identification of the CC027/GeniUnc strain as an orally reactive model of peanut allergy.不同鼠种间的遗传多样性使得 CC027/GeniUnc 鼠种成为一种可口服激发的花生过敏模型。
J Allergy Clin Immunol. 2019 Mar;143(3):1027-1037.e7. doi: 10.1016/j.jaci.2018.10.009. Epub 2018 Oct 19.
7
The role of gastrointestinal permeability in food allergy.胃肠道通透性在食物过敏中的作用。
Ann Allergy Asthma Immunol. 2018 Aug;121(2):168-173. doi: 10.1016/j.anai.2018.05.010. Epub 2018 May 25.
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Peanut allergens alter intestinal barrier permeability and tight junction localisation in Caco-2 cell cultures.花生过敏原会改变Caco-2细胞培养物中的肠道屏障通透性和紧密连接定位。
Cell Physiol Biochem. 2014;33(6):1758-77. doi: 10.1159/000362956. Epub 2014 May 23.
9
Intestinal mast cell levels control severity of oral antigen-induced anaphylaxis in mice.肠道肥大细胞水平控制了口服抗原诱导的小鼠过敏反应的严重程度。
Am J Pathol. 2012 Apr;180(4):1535-46. doi: 10.1016/j.ajpath.2011.12.036. Epub 2012 Feb 7.
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